Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 1; pp. 250 - 259
• Main Authors: Xu, Jing, Lloyd, David J., Hale, Clarence, Stanislaus, Shanaka, Chen, Michelle, Sivits, Glenn, Vonderfecht, Steven, Hecht, Randy, Li, Yue-Sheng, Lindberg, Richard A., Chen, Jin-Long, Young Jung, Dae, Zhang, Zhiyou, Ko, Hwi-Jin, Kim, Jason K., Véniant, Murielle M.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2009
• Subjects: Adipocytes; Adiposity - drug effects; Animals; Biological and medical sciences; Blood Glucose - metabolism; Blotting, Western; Body fat; Body Weight - drug effects; Calorimetry; Care and treatment; Cholesterol; Diabetes; Diabetes. Impaired glucose tolerance; Diet; Dietary Fats - administration & dosage; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Energy Metabolism - drug effects; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty acids; Fatty liver; Fatty Liver - metabolism; Fatty Liver - physiopathology; Fatty Liver - prevention & control; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblast Growth Factors - pharmacology; Fibroblasts; Gastroenterology. Liver. Pancreas. Abdomen; Gene expression; Glucagon; Glucokinase - genetics; Glucokinase - metabolism; Glucose; Glucose Clamp Technique; Growth factors; Health aspects; Insulin - blood; Insulin resistance; Insulin Resistance - physiology; Kinases; Lipids; Lipids - blood; Liver; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolic diseases; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Obesity; Obesity - drug therapy; Obesity - etiology; Obesity - physiopathology; Other diseases. Semiology; Pharmacology & Therapeutics; Proteins; Pyruvate Kinase - genetics; Pyruvate Kinase - metabolism; Recombinant Proteins - metabolism; Recombinant Proteins - pharmacology; Research design; Reverse Transcriptase Polymerase Chain Reaction; Sterols; United States; Endocrinopathy; Fibroblast growth factor; Obesity; Pancreatic hormone; Diabetes mellitus; Rodentia; Nutrition disorder; Hepatic disease; Insulin; Feeding; Vertebrata; Sensitivity; Mammalia; Fatty liver; Diet; Mouse; Animal; Digestive diseases; Nutritional status
• ISSN: 0012-1797; 1939-327X; 1939-327X
• DOI: 10.2337/db08-0392

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice Jing Xu 1 , David J. Lloyd 1 , Clarence Hale 1 , Shanaka Stanislaus 1 , Michelle Chen 1 , Glenn Sivits 1 , Steven Vonderfecht 2 , Randy Hecht 3 , Yue-Shen...