Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice

• Published in: Nature communications Vol. 8; no. 8; pp. 734 - 12
• Main Authors: 裏出 良博, LAZARUS MICHAEL, Oishi Yo, Xu Qi, Wang Lu, Zhang Bin-Jia, Takahashi Koji, Takata Yohko, Luo Yan-Jia, Cherasse Yoan, Schiffmann Serge N., de Kerchove d'Exaerde Alban, Urade Yoshihiro, Qu Wei-Min, Huang Zhi-Li, Lazarus Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 29.09.2017; Nature Publishing Group UK; Nature Portfolio
• Subjects: 631/378/1385/1814; 631/378/1385/2641; 631/378/1385/519; 631/378/1662; 631/378/3920; Adenosine; Animals; Arousal; Brain; Circadian Rhythm; Circadian rhythms; Cognitive ability; Emotional factors; Female; Humanities and Social Sciences; Inhibition (psychology); Male; Mice; Mice, Inbred C57BL; Motivation; multidisciplinary; Neurons; Nuclei; Nucleus accumbens; Nucleus Accumbens - physiology; Pallidum (ventral); Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos - metabolism; Receptor, Adenosine A2A - metabolism; Receptor, Adenosine A2A - physiology; Reinforcement; Rodents; Science; Science (multidisciplinary); Sleep; Sleep - physiology; Sleep and wakefulness; Stimuli

Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep–wake behaviour; however, the precise circuit mechanisms underlying their effe...