Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation

• Published in: Brain, behavior, and immunity Vol. 75; pp. 72 - 83
• Main Authors: Albrecht, Daniel S., Forsberg, Anton, Sandström, Angelica, Bergan, Courtney, Kadetoff, Diana, Protsenko, Ekaterina, Lampa, Jon, Lee, Yvonne C., Höglund, Caroline Olgart, Catana, Ciprian, Cervenka, Simon, Akeju, Oluwaseun, Lekander, Mats, Cohen, George, Halldin, Christer, Taylor, Norman, Kim, Minhae, Hooker, Jacob M., Edwards, Robert R., Napadow, Vitaly, Kosek, Eva, Loggia, Marco L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2019
• Subjects: Acetamides - metabolism; Adult; Astrocytes; Astrocytes - metabolism; Brain - metabolism; Carbon Radioisotopes - metabolism; Chronic overlapping pain conditions; Deprenyl-D2; Female; Fibromyalgia; Fibromyalgia - diagnostic imaging; Fibromyalgia - metabolism; Fibromyalgia - physiopathology; Functional pain; Humans; Male; Microglia; Microglia - metabolism; Middle Aged; MRI/PET; Neuroglia - metabolism; Neuroglia - physiology; Neuroimmunology; Neuroimmunomodulation - physiology; Neuroinflammation; Pain - metabolism; Pain - physiopathology; Positron emission tomography; Positron-Emission Tomography - methods; Pyridines - metabolism; Receptors, GABA - metabolism; TSPO; Astrocytes; Fibromyalgia; Neuroinflammation; TSPO; Deprenyl-D2; Functional pain; Neuroimmunology; MRI/PET; Positron emission tomography; Chronic overlapping pain conditions; Microglia

•Fibromyalgia patients exhibit elevated cortical levels of [11C]PBR28 signal.•[11C]PBR28 signal was correlated with subjective fatigue in patients.•Results from [11C]PBR28 SUVR and VT analyses show strong regional overlap.•No differences in [11C]-L-deprenyl-D2 signal implicate microglia, not astrocy...