Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo - Sakamoto, Kotaro; Masutani, Teruaki; Hirokawa, Takatsugu (Scientific Reports, 2020)
Keywords: 631/154; 631/67; Amino Acid Sequence; Amino acids; Animals; Antineoplastic Agents; Cancer therapies; Cell Line, Tumor; Cell Proliferation; Cell Proliferation - drug effects; Cell Proliferation - genetics; Chemotherapy; Deoxycytidine; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Deoxycytidine - pharmacology; Drug delivery; Drug development; Drug Therapy, Combination; Gemcitabine; Genes, ras; Genes, ras - genetics; H-Ras protein; Humanities and Social Sciences; Intravenous administration; K-Ras protein; Lung cancer; Lung Neoplasms; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Medicine; Mice; Molecular Targeted Therapy; multidisciplinary; Mutation; Neoplasm Transplantation; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Peptides; Peptides - administration & dosage; Peptides - chemistry; Peptides - pharmacology; Protein interaction; Q; R; Ras protein; Rats; Science; Science (multidisciplinary); Therapeutic targets; Xenografts