Pathogenesis of Terson syndrome

• Published in: Indian journal of ophthalmology Vol. 70; no. 12; pp. 4130 - 4137
• Main Author: Hayreh, Sohan
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.12.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Angiography; Arteries; Blood pressure; Capillaries; Care and treatment; central retinal vein compression; Cerebrospinal fluid; Compression; Decompression; Development and progression; Engorgement; Eye; Fluorescein; Hemorrhage; Humans; Occlusion; Ophthalmic Artery; Optic nerve; Pathogenesis; Retina; Retinal Artery; Retinal hemorrhage; Retinal Hemorrhage - diagnosis; Retinal Hemorrhage - etiology; retinal hemorrhages; Retinal Vein; Special Original - A Tribute to Prof Sohan Singh Hayreh; subarachnoid hemorrhage; Subarachnoid space; terson syndrome; Veins & arteries; India; Terson syndrome; retinal hemorrhages; subarachnoid hemorrhage; Central retinal vein compression
• DOI: 10.4103/ijo.IJO_1359_22
• ISSN: 0301-4738

Purpose: The aim of this experimental study was to investigate the pathogenesis of Terson syndrome (TS), which currently is controversial. Methods: The central retinal artery (in 39 orbits), posterior ciliary arteries (in 8 orbits), and central retinal vein (CRV in 21 orbits) were occluded in rhesus monkeys by exposing them to lateral orbitotomy. Fundus examination and fluorescein fundus angiography were performed before and immediately after cutting the vessels and serially thereafter during the follow-up period. The rationale of the experimental study design is discussed. Results: In eyes with central retinal artery occlusion, retinal hemorrhages were seen soon after the procedure in 7 eyes, and on follow-up in a total of 15 eyes. In posterior ciliary artery occlusion, retinal hemorrhages were seen soon after the procedure in one eye, and on follow-up in a total of three eyes. In eyes with CRV, all eyes had extensive scattered retinal hemorrhages. Conclusion: The findings of this experimental study, and my basic, experimental, and comprehensive clinical studies on CRVO, suggest the following concept of the pathogenesis of TS: Compression of the CRV plays a crucial role in the development of TS. The CRV is compressed, as it lies in the subarachnoid space of the optic nerve sheath, by raised cerebrospinal fluid pressure and/or accumulated blood. This results in retinal venous stasis and raised venous pressure in the retinal veins, leading to venous engorgement, rupture of the retinal capillaries and retinal hemorrhages. The clinical importance of compression of the CRV and not occlusion of CRV in TS is that optic nerve sheath decompression by opening it and releasing the blood and raised cerebrospinal fluid (CSF) pressure, would result in immediate decompressing of the CRV in the subarachnoid space and restoration of normal circulation and prevent visual loss.