The Effects of Amiloride and Age on Oxygen Consumption Coupled to Electrogenic Sodium Transport in the Human Sigmoid Colon

• Published in: Saudi journal of gastroenterology Vol. 21; no. 5; pp. 290 - 294
• Main Authors: Carra, Graciela E., Matus, Daniel, Ibáñez, Jorge E., Saraví, Fernando D.
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt Ltd 01.09.2015; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Aerobic bacteria; Aerobic metabolism; Age; Age Factors; Aged; Aldosterone; Amiloride; Amiloride - pharmacology; Cations, Monovalent - metabolism; Colon (Anatomy); Colon, Sigmoid - drug effects; Colon, Sigmoid - metabolism; Diuretics - pharmacology; Dosage and administration; ENaC; Epithelial Sodium Channel Blockers - pharmacology; Epithelium - drug effects; Epithelium - metabolism; Female; Genetic aspects; Humans; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Ion Transport - drug effects; Male; Medical research; Medicine, Experimental; Middle Aged; Original; Original Article; Oxygen; Oxygen consumption (Metabolism); Oxygen Consumption - drug effects; Physiological aspects; Sodium; Sodium - metabolism; Sodium in the body; Ussing chamber; United States; Argentina; amiloride; Ussing chamber; ENaC; Aerobic metabolism

Background/Aim: Aerobic metabolism is necessary for ion transport in many transporting epithelia, including the human colonic epithelium. We assessed the effects of the epithelial sodium channel blocker, amiloride, on oxygen consumption and short-circuit current of the human sigmoid epithelium to de...