Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics

• Published in: Angewandte Chemie International Edition Vol. 55; no. 19; pp. 5842 - 5845
• Main Authors: Oueis, Emilia, Jaspars, Marcel, Westwood, Nicholas J., Naismith, James H.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Blackwell Publishing Ltd 04.05.2016; Wiley; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Edition: International ed. in English
• Subjects: Amino Acid Sequence; biotransformation; Chemistry; Chemistry, Multidisciplinary; Communication; Communications; cyanobactin; cyclic peptides; Cyclization; Enzymes; Peptide Hydrolases - metabolism; Peptides; Peptides, Cyclic - chemistry; Peptides, Cyclic - metabolism; peptidomimetics; Physical Sciences; Science & Technology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; triazole; Triazoles - chemistry; cyclic peptides; biotransformation; DRUG DISCOVERY; CHEMISTRY; cyanobactin; peptidomimetics; CYCLIZATION; triazole

The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme‐mediated methods remain of great interest in terms of synthetic utility. To dat...