Hippocampal–prefrontal input supports spatial encoding in working memory

• Published in: Nature (London) Vol. 522; no. 7556; pp. 309 - 314
• Main Authors: Spellman, Timothy, Rigotti, Mattia, Ahmari, Susanne E., Fusi, Stefano, Gogos, Joseph A., Gordon, Joshua A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.06.2015; Nature Publishing Group
• Subjects: 631/378/1595/1554; 631/378/1595/1637; 631/378/1595/2618; 64/60; 9/10; 9/26; 9/30; Action Potentials; Afferent Pathways - physiology; Animals; Brain; Cognition & reasoning; Cues; Hippocampus (Brain); Hippocampus - cytology; Hippocampus - physiology; Humanities and Social Sciences; Male; Memory; Memory, Short-Term - physiology; Mice; Models, Neurological; multidisciplinary; Optogenetics; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - cytology; Prefrontal Cortex - physiology; Science; Short-term memory; Space Perception - physiology; Spatial Memory - physiology

Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and hippocampus are known to contribute jointly to successful spatial working memory, the anatomical pathway and temporal wi...