Cytoplasmic chromatin triggers inflammation in senescence and cancer

• Published in: Nature (London) Vol. 550; no. 7676; pp. 402 - 406
• Main Authors: Dou, Zhixun, Ghosh, Kanad, Vizioli, Maria Grazia, Zhu, Jiajun, Sen, Payel, Wangensteen, Kirk J., Simithy, Johayra, Lan, Yemin, Lin, Yanping, Zhou, Zhuo, Capell, Brian C., Xu, Caiyue, Xu, Mingang, Kieckhaefer, Julia E., Jiang, Tianying, Shoshkes-Carmel, Michal, Tanim, K. M. Ahasan Al, Barber, Glen N., Seykora, John T., Millar, Sarah E., Kaestner, Klaus H., Garcia, Benjamin A., Adams, Peter D., Berger, Shelley L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.10.2017; Nature Publishing Group
• Subjects: 13; 13/1; 13/106; 13/109; 13/51; 13/89; 14; 14/19; 59; 59/5; 631/67; 631/80/509; Aging (Biology); AMP; Animals; Cancer; Cell Line, Tumor; Cellular Senescence - genetics; Chromatin; Chromatin - immunology; Chromatin - metabolism; Cyclic GMP; Cytokines - immunology; Cytokines - metabolism; Cytoplasm; Cytoplasm - genetics; Cytoplasm - immunology; Deoxyribonucleic acid; DNA; DNA damage; Female; Fragments; Gene expression; Genotype & phenotype; Health aspects; Humanities and Social Sciences; Humans; Immunity; Immunity, Innate; Infections; Inflammation; Inflammation - genetics; Inflammation - immunology; Inflammation - pathology; Innate immunity; Interferon; Ionizing radiation; Kinases; letter; Liver - metabolism; Male; Membrane Proteins - deficiency; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; multidisciplinary; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - pathology; Nuclei; Nuclei (cytology); Nucleotidyltransferases - metabolism; Oncogene Protein p21(ras) - genetics; Oncogene Protein p21(ras) - immunology; Phosphorylation; Physiological aspects; Radiation; Radiation, Ionizing; Rodents; Science; Senescence
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/nature24050

Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer. Tumours feel the sting from chromatin It has been obse...