Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia

• Published in: Communications biology Vol. 5; no. 1; pp. 1288 - 15
• Main Authors: Salles, Jérôme, Chanet, Audrey, Guillet, Christelle, Vaes, Anouk MM, Brouwer-Brolsma, Elske M., Rocher, Christophe, Giraudet, Christophe, Patrac, Véronique, Meugnier, Emmanuelle, Montaurier, Christophe, Denis, Philippe, Le Bacquer, Olivier, Blot, Adeline, Jourdan, Marion, Luiking, Yvette, Furber, Matthew, Van Dijk, Miriam, Tardif, Nicolas, Yves Boirie, Y., Walrand, Stéphane
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 45/61; 45/77; 631/443/810; 64/110; 64/60; 692/699/1702; 82/58; Aged; Animals; Biology; Biomedical and Life Sciences; Biosynthesis; Dietary supplements; Electron transport; Energy expenditure; Energy output; Food and Nutrition; Humans; Life Sciences; Mice; Mitochondria; Mitochondria - metabolism; Muscle, Skeletal - pathology; Musculoskeletal system; Myotubes; Older people; Oxidative phosphorylation; Oxidative Stress; Phosphorylation; Rats; Sarcopenia; Sarcopenia - metabolism; Skeletal muscle; Transgenic mice; Vitamin D; Vitamin D - metabolism; Vitamin D - pharmacology; Vitamin D Deficiency - metabolism; Vitamin D Deficiency - pathology; Vitamin D receptors; Vitamin deficiency

Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP p...