Humoral signatures of protective and pathological SARS-CoV-2 infection in children

• Published in: Nature medicine Vol. 27; no. 3; pp. 454 - 462
• Main Authors: Bartsch, Yannic C., Wang, Chuangqi, Zohar, Tomer, Fischinger, Stephanie, Atyeo, Caroline, Burke, John S., Kang, Jaewon, Edlow, Andrea G., Fasano, Alessio, Baden, Lindsey R., Nilles, Eric J., Woolley, Ann E., Karlson, Elizabeth W., Hopke, Alex R., Irimia, Daniel, Fischer, Eric S., Ryan, Edward T., Charles, Richelle C., Julg, Boris D., Lauffenburger, Douglas A., Yonker, Lael M., Alter, Galit
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2021; Nature Publishing Group
• Subjects: 631/250/2152/2153; 631/250/2152/2153/1291; 631/250/255; 631/250/255/2514; 692/420; Adolescent; Adult; Adults; Age of Onset; Aged; Antibodies; Antibodies, Neutralizing - analysis; Antibodies, Neutralizing - blood; Antibodies, Viral - analysis; Antibodies, Viral - blood; Asymptomatic Infections; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carrier State - blood; Carrier State - epidemiology; Child; Child, Preschool; Children; Cohort Studies; Complications and side effects; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - epidemiology; COVID-19 - pathology; Demographic aspects; Epidemics; Female; Genetic aspects; Humans; Immune response; Immunity - physiology; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin G; Immunoglobulin G - blood; Infant; Infant, Newborn; Infectious Diseases; Inflammation; Leukocytes (neutrophilic); Male; Metabolic Diseases; Middle Aged; Molecular Medicine; Monocytes; Multisystem inflammatory syndrome in children; Neurosciences; Pandemics; Pathogenesis; Phenotypes; Respiratory diseases; Respiratory failure; SARS-CoV-2 - immunology; Serology; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - epidemiology; Viral diseases; Young Adult; United States

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS...