Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool

• Published in: Nature (London) Vol. 522; no. 7554; pp. 94 - 97
• Main Authors: Mesa, Kailin R., Rompolas, Panteleimon, Zito, Giovanni, Myung, Peggy, Sun, Thomas Y., Brown, Samara, Gonzalez, David G., Blagoev, Krastan B., Haberman, Ann M., Greco, Valentina
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.06.2015; Nature Publishing Group
• Subjects: 13/51; 14/28; 14/69; 631/532/2118/2438; 631/532/2139; 64/60; 96/1; 96/31; Animals; Apoptosis; beta Catenin - metabolism; Cell Death; Dermis - cytology; Dermis - metabolism; Epithelial Cells - cytology; Epithelial Cells - metabolism; Genetic aspects; Hair; Hair Follicle - cytology; Hair Follicle - metabolism; Homeostasis; Humanities and Social Sciences; letter; Mice; multidisciplinary; Phagocytes - cytology; Phagocytosis; Physiological aspects; Regeneration; Rodents; Science; Signal Transduction; Stem Cell Niche - physiology; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Tissues; Transforming Growth Factor beta - metabolism; United States

Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem ce...