Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

• Published in: Nature medicine Vol. 22; no. 4; pp. 397 - 403
• Main Authors: Song, SungWon, Miranda, Carlos J, Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E, Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K, Foust, Kevin D, McConnell, Michael J, Walker, Christopher M, Kaspar, Brian K
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2016; Nature Publishing Group
• Subjects: 13; 13/1; 13/100; 42; 42/44; 42/89; 631/378/371; 631/378/87; Aged; Aged, 80 and over; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - pathology; Analysis; Animals; Astrocytes - metabolism; Astrocytes - pathology; Biomedicine; Cadaver; Cancer Research; Cell Death - genetics; Disease Models, Animal; Female; Gene Expression Regulation; Genetic aspects; Histocompatibility antigens; Histocompatibility Antigens Class I - biosynthesis; Histocompatibility Antigens Class I - genetics; HLA histocompatibility antigens; Humans; Immune system; Infectious Diseases; Major histocompatibility complex; Male; Metabolic Diseases; Mice; Mice, Transgenic; Middle Aged; Molecular Medicine; Mortality; Motor Neurons - pathology; Mutation; Neurons; Neurosciences; Pathogenesis; Receptors, KIR3DL2 - genetics; Superoxide Dismutase - genetics; Toxicity; Ohio

Expression of MHC class I molecules on motor neurons protects them from astrocyte-induced toxicity in ALS. Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to motor neurons (MNs) and play a non–cell autonomous role in disease pathogenesis. The mechanisms underl...