Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

• Published in: The Journal of clinical investigation Vol. 119; no. 8; pp. 2343 - 2358
• Main Authors: Alvarez-Díaz, Silvia, Valle, Noelia, García, José Miguel, Peña, Cristina, Freije, José M P, Quesada, Víctor, Astudillo, Aurora, Bonilla, Félix, López-Otín, Carlos, Muñoz, Alberto
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.08.2009
• Subjects: Alfacalcidol; beta Catenin - antagonists & inhibitors; Biomedical research; Cadherins - analysis; Calcifediol; Calcitriol - pharmacology; Care and treatment; Cell Cycle; Cell Differentiation; Cell growth; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Chemical properties; Colon cancer; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; Cystatins - genetics; Cystatins - physiology; Epithelium - pathology; Gene expression; Genes; Genes, myc; Genes, Tumor Suppressor - physiology; Genetic aspects; Health aspects; Humans; Mesoderm - pathology; Promoter Regions, Genetic; Proteins; Receptors, Calcitriol - analysis; Tumor suppressor genes; Tumors; Vitamin D; Spain

The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] has wide but not fully understood antitumor activity. A previous transcriptomic analysis of 1alpha,25(OH)2D3 action on human colon cancer cells revealed cystatin D (CST5), which encodes an inhibitor of several cysteine...