Delayed production of neutralizing antibodies correlates with fatal COVID-19

• Published in: Nature medicine Vol. 27; no. 7; pp. 1178 - 1186
• Main Authors: Lucas, Carolina, Klein, Jon, Sundaram, Maria E., Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Mohanty, Subhasis, Huang, Jiefang, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Vogels, Chantal B. F., Muenker, M. Catherine, Chang, C-Hong, Casanovas-Massana, Arnau, Moore, Adam J., Zell, Joseph, Fournier, John B., Wyllie, Anne L., Campbell, Melissa, Lee, Alfred I., Chun, Hyung J., Grubaugh, Nathan D., Schulz, Wade L., Farhadian, Shelli, Dela Cruz, Charles, Ring, Aaron M., Shaw, Albert C., Wisnewski, Adam V., Yildirim, Inci, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2021; Nature Publishing Group
• Subjects: 631/250/2152/2153/1291; 631/250/255/2514; Aged; Aged, 80 and over; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antiviral drugs; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carrier State - immunology; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - mortality; COVID-19 - prevention & control; COVID-19 Vaccines - therapeutic use; Data recovery; Female; Humans; IgG antibody; Immune response; Immune response (humoral); Immunity, Humoral; Immunoglobulin G; Immunoglobulin G - immunology; Infectious Diseases; Kinetics; Length of Stay - statistics & numerical data; Male; Medical research; Medicine, Experimental; Metabolic Diseases; Middle Aged; Molecular Medicine; Mortality; Neurosciences; Neutralization; Neutralizing; Patients; Physiological aspects; SARS-CoV-2 - immunology; Seroconversion; Severity of Illness Index; Spike Glycoprotein, Coronavirus - immunology; Time dependence; Time Factors; Viral antibodies; Viral diseases; United States

Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes remain unclear. In this study, we analyzed humoral immune responses in 229 patients with asym...