MX2 is an interferon-induced inhibitor of HIV-1 infection

• Published in: Nature (London) Vol. 502; no. 7472; pp. 563 - 566
• Main Authors: Kane, Melissa, Yadav, Shalini S., Bitzegeio, Julia, Kutluay, Sebla B., Zang, Trinity, Wilson, Sam J., Schoggins, John W., Rice, Charles M., Yamashita, Masahiro, Hatziioannou, Theodora, Bieniasz, Paul D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.10.2013; Nature Publishing Group
• Subjects: 38/109; 38/39; 631/326/596/2556; Active Transport, Cell Nucleus; Antiretroviral agents; Capsid - metabolism; Cell Division; Cell Line; Cell Nucleus - metabolism; Cell Nucleus - virology; Cells, Cultured; Deoxyribonucleic acid; DNA; Gene expression; Genetic aspects; Health aspects; HIV infection; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - metabolism; HIV Infections - prevention & control; HIV-1 - immunology; HIV-1 - physiology; Host-parasite relationships; Humanities and Social Sciences; Humans; Interferon; Interferon-alpha - immunology; letter; multidisciplinary; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutation; Myxovirus Resistance Proteins - genetics; Myxovirus Resistance Proteins - metabolism; Physiological aspects; Plasmids; Proteins; Reverse Transcription; RNA Interference; Science; Transcriptome; Virus Replication; Viruses; United States

MX2 is shown to be an interferon-induced inhibitor of HIV-1 infection, and this antiviral activity may involve the inhibition of nuclear import of subviral complexes. Human MX2 protein is an HIV-1 resistance factor Two groups report in this issue of Nature that the human interferon-induced GTP-bindi...