Brain Serotonin 1A Receptor Binding as a Predictor of Treatment Outcome in Major Depressive Disorder

• Published in: Biological psychiatry (1969) Vol. 74; no. 10; pp. 760 - 767
• Main Authors: Miller, Jeffrey M., Hesselgrave, Natalie, Ogden, R. Todd, Zanderigo, Francesca, Oquendo, Maria A., Mann, J. John, Parsey, Ramin V.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.11.2013; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Antidepressant; Antidepressive Agents, Second-Generation - administration & dosage; Antidepressive Agents, Second-Generation - therapeutic use; Biological and medical sciences; Citalopram - administration & dosage; Citalopram - therapeutic use; Depression; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - metabolism; Female; Humans; Male; Medical sciences; Miscellaneous; Mood disorders; Neuropharmacology; PET imaging; Pharmacology. Drug treatments; Positron-Emission Tomography; prediction; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Raphe Nuclei - metabolism; Receptor, Serotonin, 5-HT1A - metabolism; serotonin 1A receptor; Treatment Outcome; Antidepressant; prediction; depression; PET imaging; serotonin 1A receptor; treatment outcome; Radionuclide study; Mood disorder; Psychotropic; Treatment efficiency; Central nervous system; Prediction; Depression; Encephalon; 5-HT1A Serotonine receptor; Antidepressant agent; Predictive factor; Positron emission tomography

We previously reported higher serotonin 1A receptor (5-HT1A) binding in subjects with major depressive disorder (MDD) during a major depressive episode using positron emission tomography imaging with [11C]WAY-100635. 5-HT1A receptor binding is also associated with treatment outcome after nonstandard...