Short-term cold exposure supports human Treg induction in vivo

• Published in: Molecular Metabolism Vol. 28; pp. 73 - 82
• Main Authors: Becker, Maike, Serr, Isabelle, Salb, Victoria K., Ott, Verena B., Mengel, Laura, Blüher, Matthias, Weigmann, Benno, Hauner, Hans, Tschöp, Matthias H., Daniel, Carolin
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.10.2019; Elsevier BV; Elsevier
• Subjects: Acetanilides; Adipose Tissue, Brown; Adrenergic beta-Agonists; Adult; Animals; Beta3-adrenergic stimulation; Cold Temperature; Female; Human adipose tissue; Humanized mice; Humans; Immunometabolism; Internal medicine; Male; Mice; Middle Aged; Mirabegron; Original; Original Article; RC31-1245; Receptors, Adrenergic, beta; Regulatory T cell; Regulatory T Cell ; Human Adipose Tissue ; Beta3-adrenergic Stimulation ; Mirabegron ; Immunometabolism ; Humanized Mice; T-Lymphocytes, Regulatory; Thiazoles; Young Adult; Immunometabolism; Humanized mice; Beta3-adrenergic stimulation; Mirabegron; Regulatory T cell; Human adipose tissue

Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly prone to obesity-associated inflammation. Next to their canonic...