Expression of activation markers on basophils in a controlled model of anaphylaxis
Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis. The study's goals were to assess the baseline expres...
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| Published in | Journal of allergy and clinical immunology Vol. 119; no. 5; pp. 1181 - 1188 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.05.2007
Elsevier Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined
in vivo in anaphylaxis.
The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between
in vitro and
in vivo activation marker expression.
Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after
in vitro stimulation with insect venom for activation marker expression and histamine release.
Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after
in vitro venom stimulation than after
in vivo challenge.
Broader shifts in expression of basophil activation markers after
in vivo challenge occurred among subjects with a history of
in vivo systemic anaphylaxis despite venom immunotherapy.
Basophil activation markers may be potential biomarkers for anaphylaxis. |
|---|---|
| AbstractList | Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined
in vivo in anaphylaxis.
The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between
in vitro and
in vivo activation marker expression.
Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after
in vitro stimulation with insect venom for activation marker expression and histamine release.
Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after
in vitro venom stimulation than after
in vivo challenge.
Broader shifts in expression of basophil activation markers after
in vivo challenge occurred among subjects with a history of
in vivo systemic anaphylaxis despite venom immunotherapy.
Basophil activation markers may be potential biomarkers for anaphylaxis. Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis. The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between in vitro and in vivo activation marker expression. Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after in vitro stimulation with insect venom for activation marker expression and histamine release. Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after in vitro venom stimulation than after in vivo challenge. Broader shifts in expression of basophil activation markers after in vivo challenge occurred among subjects with a history of in vivo systemic anaphylaxis despite venom immunotherapy. Basophil activation markers may be potential biomarkers for anaphylaxis. Background: Anaphylaxis has variable clinical presentations and Background: Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis. Objective: The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between in vitro and in vivo activation marker expression. Methods: Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after in vitro stimulation with insect venom for activation marker expression and histamine release. Results: Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after in vitro venom stimulation than after in vivo challenge. Conclusion: Broader shifts in expression of basophil activation markers after in vivo challenge occurred among subjects with a history of in vivo systemic anaphylaxis despite venom immunotherapy. Clinical implications: Basophil activation markers may be potential biomarkers for anaphylaxis. Background Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examinedin vivoin anaphylaxis. Objective The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship betweenin vitroandin vivoactivation marker expression. Methods Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined afterin vitrostimulation with insect venom for activation marker expression and histamine release. Results Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater afterin vitrovenom stimulation than afterin vivochallenge. Conclusion Broader shifts in expression of basophil activation markers afterin vivochallenge occurred among subjects with a history ofin vivosystemic anaphylaxis despite venom immunotherapy. Clinical implications Basophil activation markers may be potential biomarkers for anaphylaxis. Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis.BACKGROUNDAnaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis.The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between in vitro and in vivo activation marker expression.OBJECTIVEThe study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between in vitro and in vivo activation marker expression.Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after in vitro stimulation with insect venom for activation marker expression and histamine release.METHODSPatients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after in vitro stimulation with insect venom for activation marker expression and histamine release.Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after in vitro venom stimulation than after in vivo challenge.RESULTSOf 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after in vitro venom stimulation than after in vivo challenge.Broader shifts in expression of basophil activation markers after in vivo challenge occurred among subjects with a history of in vivo systemic anaphylaxis despite venom immunotherapy.CONCLUSIONBroader shifts in expression of basophil activation markers after in vivo challenge occurred among subjects with a history of in vivo systemic anaphylaxis despite venom immunotherapy.Basophil activation markers may be potential biomarkers for anaphylaxis.CLINICAL IMPLICATIONSBasophil activation markers may be potential biomarkers for anaphylaxis. Background Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis. Objective The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between in vitro and in vivo activation marker expression. Methods Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after in vitro stimulation with insect venom for activation marker expression and histamine release. Results Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after in vitro venom stimulation than after in vivo challenge. Conclusion Broader shifts in expression of basophil activation markers after in vivo challenge occurred among subjects with a history of in vivo systemic anaphylaxis despite venom immunotherapy. Clinical implications Basophil activation markers may be potential biomarkers for anaphylaxis. |
| Author | Eckman, John A. Vasagar, Kavitha Gober, Laura M. Schroeder, John T. Sterba, Patricia M. Saini, Sarbjit S. Golden, David B.K. |
| Author_xml | – sequence: 1 givenname: Laura M. surname: Gober fullname: Gober, Laura M. – sequence: 2 givenname: John A. surname: Eckman fullname: Eckman, John A. – sequence: 3 givenname: Patricia M. surname: Sterba fullname: Sterba, Patricia M. – sequence: 4 givenname: Kavitha surname: Vasagar fullname: Vasagar, Kavitha – sequence: 5 givenname: John T. surname: Schroeder fullname: Schroeder, John T. – sequence: 6 givenname: David B.K. surname: Golden fullname: Golden, David B.K. – sequence: 7 givenname: Sarbjit S. surname: Saini fullname: Saini, Sarbjit S. email: ssaini@jhmi.edu |
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| Copyright | 2007 American Academy of Allergy, Asthma & Immunology American Academy of Allergy, Asthma & Immunology 2007 INIST-CNRS Copyright Elsevier Limited May 2007 |
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| Keywords | LL MFI FITC Anaphylaxis S activation marker LTC 4 basophil Fluorescein isothiocyanate Mean fluorescence intensity Large local Systemic Leukotriene C 4 Immunopathology Allergy Immunology Granulocyte Biological marker Models Basophil |
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| Snippet | Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing... Background Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in... Background: Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in... Background: Anaphylaxis has variable clinical presentations and |
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| SubjectTerms | activation marker Allergies Allergy and Immunology Anaphylaxis Anaphylaxis - immunology Antigens, CD - biosynthesis Antigens, Differentiation, T-Lymphocyte - biosynthesis Arthropod Venoms - adverse effects Arthropod Venoms - immunology basophil Basophils - immunology Biological and medical sciences Biomarkers Cloning Desensitization, Immunologic Flow Cytometry Food allergies Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity - immunology Immunopathology Insect Bites and Stings - immunology Lectins, C-Type Medical sciences Phosphoric Diester Hydrolases - biosynthesis Pyrophosphatases - biosynthesis Review boards Venom |
| Title | Expression of activation markers on basophils in a controlled model of anaphylaxis |
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