Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

• Published in: Behavior genetics Vol. 46; no. 2; pp. 170 - 182
• Main Authors: van den Berg, Stéphanie M., de Moor, Marleen H. M., Verweij, Karin J. H., Krueger, Robert F., Luciano, Michelle, Arias Vasquez, Alejandro, Derringer, Jaime, Esko, Tõnu, Amin, Najaf, Gordon, Scott D., Hansell, Narelle K., Hart, Amy B., Huffman, Jennifer E., Lahti, Jari, Nutile, Teresa, Teumer, Alexander, Viktorin, Alexander, Wedenoja, Juho, Abecasis, Goncalo R., Allik, Jüri, Appel, Katja, Busonero, Fabio, Campbell, Harry, Costa, Paul T., Smith, George Davey, Davies, Gail, de Wit, Harriet, Ding, Jun, Engelhardt, Barbara E., Fedko, Iryna O., Ferrucci, Luigi, Giegling, Ina, Grucza, Richard, Hartmann, Annette M., Heinonen, Kati, Henders, Anjali K., Homuth, Georg, Hottenga, Jouke-Jan, Iacono, William G., Janzing, Joost, Karlsson, Robert, Kemp, John P., Latvala, Antti, Lehtimäki, Terho, Madden, Pamela A. F., Magnusson, Patrik K. E., Marten, Jonathan, Maschio, Andrea, Mbarek, Hamdi, Medland, Sarah E., Mihailov, Evelin, Milaneschi, Yuri, Montgomery, Grant W., Nivard, Michel G., Ouwens, Klaasjan G., Palotie, Aarno, Pettersson, Erik, Polasek, Ozren, Qian, Yong, Pulkki-Råback, Laura, Raitakari, Olli T., Realo, Anu, Rose, Richard J., Ruggiero, Daniela, Schmidt, Carsten O., Slutske, Wendy S., Sorice, Rossella, Starr, John M., St Pourcain, Beate, Sutin, Angelina R., Timpson, Nicholas J., Trochet, Holly, Vermeulen, Sita, Vuoksimaa, Eero, Widen, Elisabeth, Wouda, Jasper, Wright, Margaret J., Zgaga, Lina, Porteous, David, Minelli, Alessandra, Palmer, Abraham A., Rujescu, Dan, Hayward, Caroline, Rudan, Igor, Metspalu, Andres, Kaprio, Jaakko, Deary, Ian J., Räikkönen, Katri, Keltikangas-Järvinen, Liisa, Hettema, John M., Grabe, Hans J., Penninx, Brenda W. J. H., van Duijn, Cornelia M., Evans, David M., Schlessinger, David, Pedersen, Nancy L., Terracciano, Antonio, McGue, Matt, Martin, Nicholas G., Boomsma, Dorret I.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2016; Springer Nature B.V
• Subjects: Associations; Behavioral Science and Psychology; Clinical Psychology; Coding; Cohort Studies; Consortia; Epidemiology; Extraversion; Extraversion, Psychological; Gene polymorphism; Genetic diversity; Genetics; Genome-Wide Association Study; Genomes; Health Psychology; Health status; Heritability; Humans; Inventories; Lifestyles; Medicine; Multifactorial Inheritance - genetics; Neurosciences; Non-coding RNA; Original Research; Personality; Personality - genetics; Polygenic inheritance; Polymorphism, Single Nucleotide - genetics; Psychiatry; Psychology; Psychosocial factors; Public Health; Risk Factors; Single-nucleotide polymorphism; Studies; Systematic review; Twins; Variants; Netherlands; United Kingdom > UK; United States > US; Finland; Italy; Scotland; Edinburgh Scotland; Virginia; Germany; Estonia; Personality; Common genetic variants; Imputation; Phenotype harmonization; Polygenic risk

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively sma...