Genome-Wide Association Study Implicates HLA-C01:02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia

• Published in: Biological psychiatry (1969) Vol. 72; no. 8; pp. 620 - 628
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.10.2012; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Biological and medical sciences; CACNA1I; Calcium Channels, T-Type; Databases, Genetic - statistics & numerical data; Female; Genetic Predisposition to Disease; genetics; Genome-Wide Association Study; Genotype; HLA-C Antigens - genetics; HLAC; Humans; Ireland; major histocompatibility complex; Male; Medical sciences; Middle Aged; polygene score; Polymorphism, Single Nucleotide; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Risk Factors; Schizophrenia; Schizophrenia - genetics; Young Adult; Ireland; polygene score; CACNA1I; genetics; genome-wide association study; HLAC; major histocompatibility complex; schizophrenia; Psychosis; HLA-System; Major histocompatibility system; Risk factor; Schizophrenia; Genetics

We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 directly genotyped or imputed single nucleotide polymorphisms (SNPs). A subset of this sample (270 cases a...