ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function - Schuster, Jens; Klar, Joakim; Khalfallah, Ayda; Laan, Loora; Hoeber, Jan; Fatima, Ambrin; Sequeira, Velin Marita; Jin, Zhe; Korol, Sergiy V.; Huss, Mikael; Nordgren, Ann; Anderlid, Britt Marie; et al. (Frontiers in Molecular Neuroscience, 2022)
Keywords: Age; Cell cycle; Cell differentiation; Cell fate; Convulsions & seizures; electrophysiology; Epilepsy; Excitability; Forebrain; FOXG1; Foxg1 protein; GABAergic interneurons; Gene regulation; Genes; Hippocampus; Intellectual disabilities; Interneurons; Mowat-Wilson syndrome; Neural stem cells; Neurodegeneration; neurodevelopmental disease; Neurodevelopmental disorders; Neuropathogenesis; Neuroscience; Neurosciences; Neurosciences. Biological psychiatry. Neuropsychiatry; Neurovetenskaper; Pattern formation; Pluripotency; RC321-571; Seizures; Siblings; Stem cell transplantation; Stem cells; Telencephalon; Transcription factors; transcriptional network; ZEB2; γ-Aminobutyric acid; Canada; United States--US; Sweden