PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

• Published in: Diabetes (New York, N.Y.) Vol. 62; no. 6; pp. 1876 - 1887
• Main Authors: He, Jinhan, Gao, Jie, Xu, Meishu, Ren, Songrong, Stefanovic-Racic, Maja, O'Doherty, Robert Martin, Xie, Wen
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2013
• Subjects: Ablation; Adipocytes; Analysis; Animals; Biological and medical sciences; Blotting, Western; Body composition; Calorimetry; Cellular proteins; Diabetes; Diabetes. Impaired glucose tolerance; Diet; Diet, High-Fat - adverse effects; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzymes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty acids; Glucose; Glucose Tolerance Test; Homeostasis; Hyperglycemia; Insulin resistance; Insulin Resistance - genetics; Insulin Resistance - physiology; Kinases; Medical sciences; Metabolic diseases; Metabolism; Mice; Obesity; Obesity - etiology; Obesity - genetics; Obesity - surgery; Original Research; Oxidation; Physiological aspects; Receptors, Steroid - genetics; Receptors, Steroid - metabolism; Endocrinopathy; Obesity; Diabetes mellitus; Rodentia; Nutrition disorder; Metabolic diseases; Ablation; Feeding; Target tissue resistance; Vertebrata; Mammalia; Diet; Mouse; Animal; Genetics; Insulin resistance; Nutritional status

The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablatio...