PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablatio...

Full description

Saved in:
Bibliographic Details
Published inDiabetes (New York, N.Y.) Vol. 62; no. 6; pp. 1876 - 1887
Main Authors He, Jinhan, Gao, Jie, Xu, Meishu, Ren, Songrong, Stefanovic-Racic, Maja, O'Doherty, Robert Martin, Xie, Wen
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.06.2013
Subjects
Ablation
Adipocytes
Analysis
Animals
Biological and medical sciences
Blotting, Western
Body composition
Calorimetry
Cellular proteins
Diabetes
Diabetes. Impaired glucose tolerance
Diet
Diet, High-Fat - adverse effects
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzymes
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty acids
Glucose
Glucose Tolerance Test
Homeostasis
Hyperglycemia
Insulin resistance
Insulin Resistance - genetics
Insulin Resistance - physiology
Kinases
Medical sciences
Metabolic diseases
Metabolism
Mice
Obesity
Obesity - etiology
Obesity - genetics
Obesity - surgery
Original Research
Oxidation
Physiological aspects
Receptors, Steroid - genetics
Receptors, Steroid - metabolism
Endocrinopathy
Obesity
Diabetes mellitus
Rodentia
Nutrition disorder
Metabolic diseases
Ablation
Feeding
Target tissue resistance
Vertebrata
Mammalia
Diet
Mouse
Animal
Genetics
Insulin resistance
Nutritional status
Online AccessGet full text

Cover

Abstract The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)–induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR−/− allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH2-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
AbstractList The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)--induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial [beta]-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the [PXR.sup.-/-] allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun N[H.sub.2]-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)-induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR(-/-) allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH2-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)-induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR(-/-) allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH2-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)-induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR(-/-) allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH2-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)-induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial [beta]-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR(-/-) allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH2-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)--induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the [PXR.sup.-/-] allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun N[H.sub.2]-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)–induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR−/− allele into the ob/ob background also improved body composition and relieved the diabetic phenotype. The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH2-terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablation inhibited high-fat diet (HFD)–induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial β-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling. In an independent model, introducing the PXR −/− allele into the ob / ob background also improved body composition and relieved the diabetic phenotype. The ob / ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp. Mechanistically, the metabolic benefits of PXR ablation were associated with the inhibition of c-Jun NH 2 -terminal kinase activation and downregulation of lipin-1, a novel PXR target gene. The metabolic benefit of PXR ablation was opposite to the reported prodiabetic effect of CAR ablation. Our results may help to establish PXR as a novel therapeutic target, and PXR antagonists may be used for the prevention and treatment of obesity and type 2 diabetes.
Audience Professional
Author Ren, Songrong
He, Jinhan
Xie, Wen
Xu, Meishu
Stefanovic-Racic, Maja
O'Doherty, Robert Martin
Gao, Jie
Author_xml – sequence: 1
  givenname: Jinhan
  surname: He
  fullname: He, Jinhan
  organization: Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan, China
– sequence: 2
  givenname: Jie
  surname: Gao
  fullname: Gao, Jie
  organization: Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 3
  givenname: Meishu
  surname: Xu
  fullname: Xu, Meishu
  organization: Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 4
  givenname: Songrong
  surname: Ren
  fullname: Ren, Songrong
  organization: Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 5
  givenname: Maja
  surname: Stefanovic-Racic
  fullname: Stefanovic-Racic, Maja
  organization: Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 6
  givenname: Robert Martin
  surname: O'Doherty
  fullname: O'Doherty, Robert Martin
  organization: Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 7
  givenname: Wen
  surname: Xie
  fullname: Xie, Wen
  organization: Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27485196$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/23349477$$D View this record in MEDLINE/PubMed
BookMark eNp9klFv0zAQxy00xLrCA18ARUJI8JAtjmM7eUGqCpRKRUUTiL1ZjnMpnlxnxM7Evj2XUbZ1qpAfLJ9_d777-39CjnzngZCXNDvNGZNnTU3zlGasekImtGJVynJ5cUQmWTbGZSWPyUkIl1mWCVzPyDFmFVUh5YT8-Hpxnsxqp6PtfDJzDq6tjhCSDxZiuvTNYKBJtG-SBXiI1iTrGoKNN7expQ-Dsz45x1CI2htI8PTFGnhOnrbaBXix26fk-6eP3-af09V6sZzPVqkRUsQUdFHnJjclbdoGMtO2XOAFlQI4q0vd0KwqCsNynBCkKcu6kDnlOhe1Nk0u2JS8_1v3aqi30BjwsddOXfV2q_sb1Wmr9m-8_ak23bViQlCBYk3J212Bvvs1QIhqa4MB57SHbgiKMs6LEpWkiL5-hF52Q-9xPEWLXGRcVPwBtdEOlPVth--asaiaMZYLzrngSKUHqA1qjE3i77YWw3v86QEeVwNbaw4mvNtLQCbC77jRQwiqXKz-18yONR3aYQMKP2y-3udfPRT9Tu1_tkLgzQ7QwWjX9mgNG-45WZScVuK-SdN3IfTQ3iE0G6tJNVpbjdZG9uwRa2y8tS0qYd2BjD9Gx_VY
CODEN DIAEAZ
CitedBy_id crossref_primary_10_1002_tox_24094
crossref_primary_10_1038_ijo_2015_63
crossref_primary_10_1074_jbc_M113_494575
crossref_primary_10_1194_jlr_RA119000122
crossref_primary_10_1016_j_coph_2022_102314
crossref_primary_10_1016_j_molmet_2023_101779
crossref_primary_10_1093_toxsci_kfu083
crossref_primary_10_1124_mol_118_113647
crossref_primary_10_1093_toxsci_kfae047
crossref_primary_10_1111_iep_12306
crossref_primary_10_1152_ajprenal_00390_2017
crossref_primary_10_1016_j_bcp_2024_116309
crossref_primary_10_1016_j_fct_2023_113976
crossref_primary_10_1289_EHP9262
crossref_primary_10_1186_s12987_022_00375_3
crossref_primary_10_1038_s41598_019_53101_9
crossref_primary_10_3390_cells9112445
crossref_primary_10_1111_bcpt_13004
crossref_primary_10_1016_j_cbi_2019_05_038
crossref_primary_10_1016_j_toxlet_2024_07_003
crossref_primary_10_1155_2014_637027
crossref_primary_10_2174_1389200219666180918152241
crossref_primary_10_1210_me_2015_1292
crossref_primary_10_3390_cells11071125
crossref_primary_10_1016_j_bbagrm_2016_03_002
crossref_primary_10_1016_j_fct_2019_04_007
crossref_primary_10_1016_j_molpha_2024_100014
crossref_primary_10_1126_scitranslmed_aay7591
crossref_primary_10_1016_j_bbagrm_2016_02_015
crossref_primary_10_1016_j_molmet_2020_101119
crossref_primary_10_1016_j_apsb_2024_08_029
crossref_primary_10_3389_fimmu_2022_969399
crossref_primary_10_1007_s11883_015_0507_8
crossref_primary_10_3389_fendo_2019_00039
crossref_primary_10_1097_HC9_0000000000000343
crossref_primary_10_1530_JOE_17_0536
crossref_primary_10_1093_cdn_nzaa122
crossref_primary_10_1155_2021_6889533
crossref_primary_10_1016_j_bbagrm_2016_01_006
crossref_primary_10_1186_s12302_019_0195_z
crossref_primary_10_1111_bph_15055
crossref_primary_10_1016_j_bbagrm_2016_04_010
crossref_primary_10_1080_17425255_2024_2309212
crossref_primary_10_1124_mol_117_108829
crossref_primary_10_1038_s41467_024_50198_z
crossref_primary_10_1016_j_bcp_2017_07_019
crossref_primary_10_3390_ijms222312846
crossref_primary_10_1016_j_bcp_2020_114142
crossref_primary_10_1124_mol_116_104687
crossref_primary_10_3390_ijms25094836
crossref_primary_10_1111_bph_15433
crossref_primary_10_11131_2016_101198
crossref_primary_10_3390_ijms141122052
crossref_primary_10_1038_s41419_021_03768_8
crossref_primary_10_1038_srep40988
crossref_primary_10_1016_j_apsb_2018_09_007
crossref_primary_10_1016_j_apsb_2019_10_001
crossref_primary_10_3390_cells12232752
crossref_primary_10_3390_metabo11100706
crossref_primary_10_2174_1389200219666180611083155
crossref_primary_10_1016_j_jep_2023_116365
crossref_primary_10_3389_fphar_2024_1448744
crossref_primary_10_1016_j_jep_2024_119199
crossref_primary_10_1016_j_tox_2018_08_007
crossref_primary_10_1016_j_bcp_2022_115250
crossref_primary_10_1016_j_bcp_2015_11_023
crossref_primary_10_1016_j_taap_2014_06_019
crossref_primary_10_1016_j_bcp_2022_115012
crossref_primary_10_1042_BJ20150734
crossref_primary_10_1096_fj_202301126
crossref_primary_10_7717_peerj_7743
crossref_primary_10_1016_j_bcp_2019_04_008
crossref_primary_10_3389_fphar_2022_907271
crossref_primary_10_1021_acs_chemrestox_6b00186
crossref_primary_10_1111_liv_12578
crossref_primary_10_7554_eLife_37182
crossref_primary_10_1186_1476_511X_13_24
crossref_primary_10_1074_jbc_M117_815217
crossref_primary_10_1016_j_livres_2020_03_001
crossref_primary_10_2337_db16_1225
crossref_primary_10_1016_j_bcp_2013_03_016
crossref_primary_10_1016_j_livres_2018_12_002
crossref_primary_10_1124_mol_114_097287
crossref_primary_10_1016_j_bcp_2021_114698
crossref_primary_10_1097_MOG_0000000000000816
crossref_primary_10_1210_me_2014_1355
crossref_primary_10_3390_md17100554
crossref_primary_10_1007_s00204_014_1348_x
crossref_primary_10_1016_j_bcp_2018_01_001
crossref_primary_10_1016_j_biopha_2024_116341
crossref_primary_10_1016_j_bbadis_2021_166101
crossref_primary_10_1016_j_jlr_2021_100051
crossref_primary_10_1124_dmd_123_001311
crossref_primary_10_1124_dmd_122_000862
crossref_primary_10_1124_mol_113_085753
crossref_primary_10_1371_journal_pone_0087697
crossref_primary_10_1016_j_bbagrm_2016_03_012
crossref_primary_10_1124_dmd_121_000415
crossref_primary_10_1038_nrendo_2013_226
crossref_primary_10_3390_cells10123550
crossref_primary_10_1002_med_21648
crossref_primary_10_1002_jcp_24838
crossref_primary_10_1016_j_mce_2019_02_002
crossref_primary_10_1016_j_metabol_2024_156054
crossref_primary_10_1038_s41467_025_56642_y
crossref_primary_10_4331_wjbc_v8_i2_108
crossref_primary_10_1007_s00204_024_03942_9
crossref_primary_10_1016_j_molmet_2020_100994
crossref_primary_10_1074_jbc_M113_535914
crossref_primary_10_1016_j_bcp_2014_03_019
crossref_primary_10_1124_dmd_118_081042
crossref_primary_10_3390_ijerph17249403
crossref_primary_10_1515_mr_2022_0032
crossref_primary_10_1016_j_obmed_2020_100197
crossref_primary_10_1016_j_envpol_2021_117855
crossref_primary_10_1016_j_toxlet_2022_11_021
crossref_primary_10_3390_foods11172543
crossref_primary_10_3390_ijms20153767
Cites_doi 10.1016/j.tips.2012.03.003
10.1016/j.cmet.2009.01.007
10.1371/journal.pone.0038734
10.1074/jbc.M109.016808
10.1074/jbc.M610072200
10.1194/jlr.M800204-JLR200
10.1002/hep.24140
10.1124/dmd.30.7.814
10.1016/S0092-8674(00)80900-9
10.1002/j.1552-4604.1982.tb02652.x
10.1038/nature01137
10.1056/NEJM196907102810208
10.1093/toxsci/kfs211
10.1016/S0022-2275(20)30474-0
10.1038/sj.onc.1209788
10.1124/dmd.30.7.795
10.1124/mol.111.071787
10.1124/dmd.110.035568
10.1124/mol.108.049437
10.1097/MOL.0b013e32834b4994
10.1074/jbc.M511116200
10.1042/BJ20070481
10.1073/pnas.0909731106
10.7326/0003-4819-118-7-199304010-00008
10.1038/35019116
10.1002/cncr.20071
10.1016/j.bmcl.2008.06.018
10.1101/gad.12.20.3195
10.1126/scitranslmed.3001007
10.1111/j.1464-5491.1991.tb01539.x
10.1128/MCB.24.18.7931-7940.2004
10.2337/db11-1152
10.1210/me.2007-0218
10.1074/jbc.M405423200
10.3109/00498254.2011.569773
10.1001/jama.286.16.1945
10.1634/theoncologist.12-1-99
ClassificationCodes 2831720
ContentType Journal Article
Copyright 2014 INIST-CNRS
COPYRIGHT 2013 American Diabetes Association
COPYRIGHT 2013 American Diabetes Association
Copyright American Diabetes Association Jun 2013
2013 by the American Diabetes Association. 2013
Copyright_xml – notice: 2014 INIST-CNRS
– notice: COPYRIGHT 2013 American Diabetes Association
– notice: COPYRIGHT 2013 American Diabetes Association
– notice: Copyright American Diabetes Association Jun 2013
– notice: 2013 by the American Diabetes Association. 2013
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
8GL
3V.
7RV
7X7
7XB
88E
88I
8AF
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BEC
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
HCIFZ
K9-
K9.
KB0
LK8
M0R
M0S
M1P
M2O
M2P
M7P
MBDVC
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
S0X
7X8
5PM
DOI 10.2337/db12-1039
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: High School
ProQuest Central (Corporate)
Nursing & Allied Health Database
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Public Health Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Database
eLibrary Curriculum
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
SciTech Premium Collection
Consumer Health Database (Alumni Edition)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Biological Science Collection
Consumer Health Database
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Research Library
Science Database
Biological Science Database
Research Library (Corporate)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
SIRS Editorial
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Family Health
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest One Academic Middle East (New)
SIRS Editorial
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Family Health (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Public Health
ProQuest Central Basic
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
Research Library Prep

CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central - New (Subscription)
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1939-327X
EndPage 1887
ExternalDocumentID PMC3661619
3048635141
A332655565
23349477
27485196
10_2337_db12_1039
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIDDK NIH HHS
  grantid: R01 DK083952
– fundername: NIEHS NIH HHS
  grantid: ES-019629
– fundername: NIEHS NIH HHS
  grantid: R21 ES019629
– fundername: NCATS NIH HHS
  grantid: UL1 TR000005
– fundername: NIDDK NIH HHS
  grantid: DK-083952
– fundername: NIDDK NIH HHS
  grantid: R01 DK072162
– fundername: NIDDK NIH HHS
  grantid: R01 DK058855
GroupedDBID ---
.55
.XZ
08P
0R~
18M
29F
2WC
354
4.4
53G
5GY
5RE
5RS
5VS
6PF
7RV
7X7
88E
88I
8AF
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8GL
8R4
8R5
AAFWJ
AAKAS
AAQQT
AAWTL
AAYEP
AAYOK
AAYXX
ABOCM
ABUWG
ACGFO
ACGOD
ACPRK
ADBBV
ADGHP
ADZCM
AEGXH
AENEX
AERZD
AFKRA
AHMBA
AIAGR
AIZAD
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BAWUL
BBNVY
BCU
BEC
BENPR
BES
BHPHI
BKEYQ
BKNYI
BPHCQ
BTFSW
BVXVI
CCPQU
CITATION
CS3
DIK
DU5
DWQXO
E3Z
EBS
EDB
EJD
EMOBN
EX3
F5P
FRP
FYUFA
GICCO
GNUQQ
GUQSH
GX1
H13
HCIFZ
HMCUK
HZ~
IAG
IAO
IEA
IHR
INH
INR
IOF
IPO
ITC
K-O
K2M
K9-
KQ8
L7B
LK8
M0R
M1P
M2O
M2P
M2Q
M5~
M7P
NAPCQ
O5R
O5S
O9-
OB3
OHH
OK1
OVD
P2P
PCD
PHGZM
PHGZT
PQQKQ
PROAC
PSQYO
Q2X
RHI
RPM
S0X
SJFOW
SJN
SV3
TDI
TEORI
TR2
UKHRP
VVN
W8F
WH7
WOQ
WOW
X7M
YFH
YHG
YOC
ZY1
~KM
.GJ
1CY
8F7
AAYJJ
AFFNX
AI.
BCR
BLC
C1A
H~9
IQODW
J5H
MVM
N4W
PEA
PJZUB
PPXIY
PQGLB
VH1
XOL
YQJ
ZGI
ZXP
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7XB
8FK
K9.
MBDVC
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c676t-ea4b2c2c81dfde0cff56676176e53b8ad10944c32b12e7c88b47215a26bacd263
IEDL.DBID 7X7
ISSN 0012-1797
1939-327X
IngestDate Thu Aug 21 18:36:23 EDT 2025
Fri Jul 11 15:51:49 EDT 2025
Fri Jul 25 19:37:12 EDT 2025
Tue Jun 17 20:55:16 EDT 2025
Thu Jun 12 23:01:04 EDT 2025
Tue Jun 10 20:19:44 EDT 2025
Fri Jun 27 03:55:29 EDT 2025
Tue Jun 10 19:50:47 EDT 2025
Mon Jul 21 06:03:21 EDT 2025
Mon Jul 21 09:17:28 EDT 2025
Thu Apr 24 22:53:30 EDT 2025
Tue Jul 01 03:04:10 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords Endocrinopathy
Obesity
Diabetes mellitus
Rodentia
Nutrition disorder
Metabolic diseases
Ablation
Feeding
Target tissue resistance
Vertebrata
Mammalia
Diet
Mouse
Animal
Genetics
Insulin resistance
Nutritional status
Language English
License CC BY 4.0
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c676t-ea4b2c2c81dfde0cff56676176e53b8ad10944c32b12e7c88b47215a26bacd263
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-General Information-1
content type line 14
ObjectType-Feature-3
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC3661619
PMID 23349477
PQID 1426056951
PQPubID 34443
PageCount 12
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3661619
proquest_miscellaneous_1355480011
proquest_journals_1426056951
gale_infotracmisc_A332655565
gale_infotracgeneralonefile_A332655565
gale_infotracacademiconefile_A332655565
gale_incontextgauss_8GL_A332655565
gale_incontextcollege_GICCO_A332655565
pubmed_primary_23349477
pascalfrancis_primary_27485196
crossref_primary_10_2337_db12_1039
crossref_citationtrail_10_2337_db12_1039
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-06-01
PublicationDateYYYYMMDD 2013-06-01
PublicationDate_xml – month: 06
  year: 2013
  text: 2013-06-01
  day: 01
PublicationDecade 2010
PublicationPlace Alexandria, VA
PublicationPlace_xml – name: Alexandria, VA
– name: United States
– name: New York
PublicationTitle Diabetes (New York, N.Y.)
PublicationTitleAlternate Diabetes
PublicationYear 2013
Publisher American Diabetes Association
Publisher_xml – name: American Diabetes Association
References Carter (2022031210230197400_B14) 1981; 38
Lindley (2022031210230197400_B9) 2002; 30
Gao (2022031210230197400_B27) 2012; 61
Hirosumi (2022031210230197400_B30) 2002; 420
Ekins (2022031210230197400_B39) 2008; 74
Kliewer (2022031210230197400_B2) 1998; 92
Peters (2022031210230197400_B15) 1969; 281
Bou Khalil (2022031210230197400_B32) 2009; 50
Chen (2022031210230197400_B29) 2002; 43
al-Rubeaan (2022031210230197400_B12) 1991; 8
Gao (2022031210230197400_B28) 2009; 284
Cheng (2022031210230197400_B24) 2012; 129
Pandit (2022031210230197400_B6) 1993; 118
Huang (2022031210230197400_B34)
Kodama (2022031210230197400_B20) 2004; 24
Xie (2022031210230197400_B26) 2000; 406
Preiss (2022031210230197400_B11) 2011; 22
Gao (2022031210230197400_B23) 2010; 38
Ma (2022031210230197400_B25) 2012; 7
Vallerie (2022031210230197400_B31) 2010; 2
2022031210230197400_B3
Venkatesh (2022031210230197400_B37) 2011; 80
Zhou (2022031210230197400_B19) 2006; 281
Luo (2022031210230197400_B8) 2002; 30
Suvannasankha (2022031210230197400_B16) 2007; 12
Orellana-Gavaldà (2022031210230197400_B35) 2011; 53
Das (2022031210230197400_B38) 2008; 18
Ryu (2022031210230197400_B33) 2009; 9
Howe (2022031210230197400_B7) 2011; 41
Weiser (2022031210230197400_B17) 2004; 100
Nakamura (2022031210230197400_B18) 2007; 282
Wang (2022031210230197400_B41) 2008; 22
Blumberg (2022031210230197400_B1) 1998; 12
Luna (2022031210230197400_B5) 2001; 286
Kodama (2022031210230197400_B21) 2007; 407
Dong (2022031210230197400_B36) 2009; 106
Huang (2022031210230197400_B40) 2007; 26
Takasu (2022031210230197400_B10) 1982; 125
Banner (2022031210230197400_B13) 1982; 22
Bhalla (2022031210230197400_B22) 2004; 279
Cheng (2022031210230197400_B4) 2012; 33
20736325 - Drug Metab Dispos. 2010 Dec;38(12):2091-5
8442624 - Ann Intern Med. 1993 Apr 1;118(7):529-39
19254569 - Cell Metab. 2009 Mar;9(3):240-51
9489701 - Cell. 1998 Jan 9;92(1):73-82
21295138 - Biochim Biophys Acta. 2011 Aug;1812(8):956-63
12065438 - Drug Metab Dispos. 2002 Jul;30(7):795-804
21319201 - Hepatology. 2011 Mar;53(3):821-32
21897230 - Curr Opin Lipidol. 2011 Dec;22(6):460-6
17267396 - J Biol Chem. 2007 Mar 30;282(13):9768-76
12447443 - Nature. 2002 Nov 21;420(6913):333-6
11667913 - JAMA. 2001 Oct 24-31;286(16):1945-8
17635106 - Biochem J. 2007 Nov 1;407(3):373-81
7039435 - Am Rev Respir Dis. 1982 Jan;125(1):23-7
1838051 - Diabet Med. 1991 Dec;8(10):968-70
15022284 - Cancer. 2004 Mar 15;100(6):1179-85
7040499 - J Clin Pharmacol. 1982 Feb-Mar;22(2-3):79-81
17227904 - Oncologist. 2007 Jan;12(1):99-106
21123811 - Sci Transl Med. 2010 Dec 1;2(60):60rv5
18583127 - Bioorg Med Chem Lett. 2008 Jul 15;18(14):3974-7
16556603 - J Biol Chem. 2006 May 26;281(21):15013-20
15322103 - J Biol Chem. 2004 Oct 22;279(43):45139-47
18769019 - J Lipid Res. 2009 Jan;50(1):47-58
12065440 - Drug Metab Dispos. 2002 Jul;30(7):814-22
22009939 - FASEB J. 2012 Feb;26(2):628-38
19617349 - J Biol Chem. 2009 Sep 18;284(38):25984-92
19850873 - Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6
21476904 - Xenobiotica. 2011 Jul;41(7):519-29
7294047 - Am J Hosp Pharm. 1981 Oct;38(10):1508-12
18096694 - Mol Endocrinol. 2008 Apr;22(4):838-57
15340055 - Mol Cell Biol. 2004 Sep;24(18):7931-40
5784786 - N Engl J Med. 1969 Jul 10;281(2):91-2
10935643 - Nature. 2000 Jul 27;406(6794):435-9
22723881 - PLoS One. 2012;7(6):e38734
9784494 - Genes Dev. 1998 Oct 15;12(20):3195-205
18579710 - Mol Pharmacol. 2008 Sep;74(3):662-72
16819505 - Oncogene. 2007 Jan 11;26(2):258-68
21464197 - Mol Pharmacol. 2011 Jul;80(1):124-35
22609277 - Trends Pharmacol Sci. 2012 Jun;33(6):323-30
22438574 - Diabetes. 2012 Jun;61(6):1543-51
22790967 - Toxicol Sci. 2012 Oct;129(2):456-68
12032175 - J Lipid Res. 2002 Jun;43(6):986-9
References_xml – volume: 33
  start-page: 323
  year: 2012
  ident: 2022031210230197400_B4
  article-title: Pregnane X receptor as a target for treatment of inflammatory bowel disorders
  publication-title: Trends Pharmacol Sci
  doi: 10.1016/j.tips.2012.03.003
– volume: 9
  start-page: 240
  year: 2009
  ident: 2022031210230197400_B33
  article-title: TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2009.01.007
– ident: 2022031210230197400_B3
– volume: 7
  start-page: e38734
  year: 2012
  ident: 2022031210230197400_B25
  article-title: Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0038734
– volume: 284
  start-page: 25984
  year: 2009
  ident: 2022031210230197400_B28
  article-title: The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.016808
– volume: 282
  start-page: 9768
  year: 2007
  ident: 2022031210230197400_B18
  article-title: Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M610072200
– volume: 50
  start-page: 47
  year: 2009
  ident: 2022031210230197400_B32
  article-title: The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M800204-JLR200
– volume: 53
  start-page: 821
  year: 2011
  ident: 2022031210230197400_B35
  article-title: Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation
  publication-title: Hepatology
  doi: 10.1002/hep.24140
– volume: 30
  start-page: 814
  year: 2002
  ident: 2022031210230197400_B9
  article-title: The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes
  publication-title: Drug Metab Dispos
  doi: 10.1124/dmd.30.7.814
– volume: 92
  start-page: 73
  year: 1998
  ident: 2022031210230197400_B2
  article-title: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80900-9
– volume: 125
  start-page: 23
  year: 1982
  ident: 2022031210230197400_B10
  article-title: Rifampicin-induced early phase hyperglycemia in humans
  publication-title: Am Rev Respir Dis
– volume: 22
  start-page: 79
  year: 1982
  ident: 2022031210230197400_B13
  article-title: Effects of single large doses of phenytoin on glucose homeostasis—a preliminary report
  publication-title: J Clin Pharmacol
  doi: 10.1002/j.1552-4604.1982.tb02652.x
– ident: 2022031210230197400_B34
  article-title: Sustained activation of CptR{alpha} by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice
  publication-title: FASEB J
– volume: 420
  start-page: 333
  year: 2002
  ident: 2022031210230197400_B30
  article-title: A central role for JNK in obesity and insulin resistance
  publication-title: Nature
  doi: 10.1038/nature01137
– volume: 281
  start-page: 91
  year: 1969
  ident: 2022031210230197400_B15
  article-title: Hyperglycemia with relative hypoinsulinemia in diphenylhydantoin toxicity
  publication-title: N Engl J Med
  doi: 10.1056/NEJM196907102810208
– volume: 129
  start-page: 456
  year: 2012
  ident: 2022031210230197400_B24
  article-title: Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice
  publication-title: Toxicol Sci
  doi: 10.1093/toxsci/kfs211
– volume: 43
  start-page: 986
  year: 2002
  ident: 2022031210230197400_B29
  article-title: Determination of adipocyte size by computer image analysis
  publication-title: J Lipid Res
  doi: 10.1016/S0022-2275(20)30474-0
– volume: 26
  start-page: 258
  year: 2007
  ident: 2022031210230197400_B40
  article-title: Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209788
– volume: 30
  start-page: 795
  year: 2002
  ident: 2022031210230197400_B8
  article-title: CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
  publication-title: Drug Metab Dispos
  doi: 10.1124/dmd.30.7.795
– volume: 38
  start-page: 1508
  year: 1981
  ident: 2022031210230197400_B14
  article-title: Phenytoin-induced hyperglycemia
  publication-title: Am J Hosp Pharm
– volume: 80
  start-page: 124
  year: 2011
  ident: 2022031210230197400_B37
  article-title: In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.111.071787
– volume: 38
  start-page: 2091
  year: 2010
  ident: 2022031210230197400_B23
  article-title: Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism
  publication-title: Drug Metab Dispos
  doi: 10.1124/dmd.110.035568
– volume: 74
  start-page: 662
  year: 2008
  ident: 2022031210230197400_B39
  article-title: Computational discovery of novel low micromolar human pregnane X receptor antagonists
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.108.049437
– volume: 22
  start-page: 460
  year: 2011
  ident: 2022031210230197400_B11
  article-title: Statins and the risk of new-onset diabetes: a review of recent evidence
  publication-title: Curr Opin Lipidol
  doi: 10.1097/MOL.0b013e32834b4994
– volume: 281
  start-page: 15013
  year: 2006
  ident: 2022031210230197400_B19
  article-title: A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M511116200
– volume: 407
  start-page: 373
  year: 2007
  ident: 2022031210230197400_B21
  article-title: Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene
  publication-title: Biochem J
  doi: 10.1042/BJ20070481
– volume: 106
  start-page: 18831
  year: 2009
  ident: 2022031210230197400_B36
  article-title: Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0909731106
– volume: 118
  start-page: 529
  year: 1993
  ident: 2022031210230197400_B6
  article-title: Drug-induced disorders of glucose tolerance
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-118-7-199304010-00008
– volume: 406
  start-page: 435
  year: 2000
  ident: 2022031210230197400_B26
  article-title: Humanized xenobiotic response in mice expressing nuclear receptor SXR
  publication-title: Nature
  doi: 10.1038/35019116
– volume: 100
  start-page: 1179
  year: 2004
  ident: 2022031210230197400_B17
  article-title: Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen
  publication-title: Cancer
  doi: 10.1002/cncr.20071
– volume: 18
  start-page: 3974
  year: 2008
  ident: 2022031210230197400_B38
  article-title: Synthesis of novel ketoconazole derivatives as inhibitors of the human pregnane X receptor (PXR; NR1I2; also termed SXR, PAR)
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2008.06.018
– volume: 12
  start-page: 3195
  year: 1998
  ident: 2022031210230197400_B1
  article-title: SXR, a novel steroid and xenobiotic-sensing nuclear receptor
  publication-title: Genes Dev
  doi: 10.1101/gad.12.20.3195
– volume: 2
  start-page: rv5
  year: 2010
  ident: 2022031210230197400_B31
  article-title: The role of JNK proteins in metabolism
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3001007
– volume: 8
  start-page: 968
  year: 1991
  ident: 2022031210230197400_B12
  article-title: Phenytoin-induced insulin insensitivity
  publication-title: Diabet Med
  doi: 10.1111/j.1464-5491.1991.tb01539.x
– volume: 24
  start-page: 7931
  year: 2004
  ident: 2022031210230197400_B20
  article-title: Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.24.18.7931-7940.2004
– volume: 61
  start-page: 1543
  year: 2012
  ident: 2022031210230197400_B27
  article-title: Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes
  publication-title: Diabetes
  doi: 10.2337/db11-1152
– volume: 22
  start-page: 838
  year: 2008
  ident: 2022031210230197400_B41
  article-title: The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor
  publication-title: Mol Endocrinol
  doi: 10.1210/me.2007-0218
– volume: 279
  start-page: 45139
  year: 2004
  ident: 2022031210230197400_B22
  article-title: Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M405423200
– volume: 41
  start-page: 519
  year: 2011
  ident: 2022031210230197400_B7
  article-title: The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2011.569773
– volume: 286
  start-page: 1945
  year: 2001
  ident: 2022031210230197400_B5
  article-title: Drug-induced hyperglycemia
  publication-title: JAMA
  doi: 10.1001/jama.286.16.1945
– volume: 12
  start-page: 99
  year: 2007
  ident: 2022031210230197400_B16
  article-title: Final report of toxicity and efficacy of a phase II study of oral cyclophosphamide, thalidomide, and prednisone for patients with relapsed or refractory multiple myeloma: a Hoosier Oncology Group Trial, HEM01-21
  publication-title: Oncologist
  doi: 10.1634/theoncologist.12-1-99
– reference: 17267396 - J Biol Chem. 2007 Mar 30;282(13):9768-76
– reference: 22723881 - PLoS One. 2012;7(6):e38734
– reference: 18096694 - Mol Endocrinol. 2008 Apr;22(4):838-57
– reference: 11667913 - JAMA. 2001 Oct 24-31;286(16):1945-8
– reference: 9784494 - Genes Dev. 1998 Oct 15;12(20):3195-205
– reference: 15022284 - Cancer. 2004 Mar 15;100(6):1179-85
– reference: 18583127 - Bioorg Med Chem Lett. 2008 Jul 15;18(14):3974-7
– reference: 22009939 - FASEB J. 2012 Feb;26(2):628-38
– reference: 21464197 - Mol Pharmacol. 2011 Jul;80(1):124-35
– reference: 19254569 - Cell Metab. 2009 Mar;9(3):240-51
– reference: 12065438 - Drug Metab Dispos. 2002 Jul;30(7):795-804
– reference: 17635106 - Biochem J. 2007 Nov 1;407(3):373-81
– reference: 19850873 - Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6
– reference: 12065440 - Drug Metab Dispos. 2002 Jul;30(7):814-22
– reference: 9489701 - Cell. 1998 Jan 9;92(1):73-82
– reference: 19617349 - J Biol Chem. 2009 Sep 18;284(38):25984-92
– reference: 12032175 - J Lipid Res. 2002 Jun;43(6):986-9
– reference: 10935643 - Nature. 2000 Jul 27;406(6794):435-9
– reference: 16556603 - J Biol Chem. 2006 May 26;281(21):15013-20
– reference: 12447443 - Nature. 2002 Nov 21;420(6913):333-6
– reference: 15322103 - J Biol Chem. 2004 Oct 22;279(43):45139-47
– reference: 7039435 - Am Rev Respir Dis. 1982 Jan;125(1):23-7
– reference: 21476904 - Xenobiotica. 2011 Jul;41(7):519-29
– reference: 1838051 - Diabet Med. 1991 Dec;8(10):968-70
– reference: 17227904 - Oncologist. 2007 Jan;12(1):99-106
– reference: 21319201 - Hepatology. 2011 Mar;53(3):821-32
– reference: 7294047 - Am J Hosp Pharm. 1981 Oct;38(10):1508-12
– reference: 16819505 - Oncogene. 2007 Jan 11;26(2):258-68
– reference: 20736325 - Drug Metab Dispos. 2010 Dec;38(12):2091-5
– reference: 7040499 - J Clin Pharmacol. 1982 Feb-Mar;22(2-3):79-81
– reference: 8442624 - Ann Intern Med. 1993 Apr 1;118(7):529-39
– reference: 21123811 - Sci Transl Med. 2010 Dec 1;2(60):60rv5
– reference: 18769019 - J Lipid Res. 2009 Jan;50(1):47-58
– reference: 22790967 - Toxicol Sci. 2012 Oct;129(2):456-68
– reference: 18579710 - Mol Pharmacol. 2008 Sep;74(3):662-72
– reference: 22438574 - Diabetes. 2012 Jun;61(6):1543-51
– reference: 5784786 - N Engl J Med. 1969 Jul 10;281(2):91-2
– reference: 15340055 - Mol Cell Biol. 2004 Sep;24(18):7931-40
– reference: 22609277 - Trends Pharmacol Sci. 2012 Jun;33(6):323-30
– reference: 21295138 - Biochim Biophys Acta. 2011 Aug;1812(8):956-63
– reference: 21897230 - Curr Opin Lipidol. 2011 Dec;22(6):460-6
SSID ssj0006060
Score 2.4514954
Snippet The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that...
SourceID pubmedcentral
proquest
gale
pubmed
pascalfrancis
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1876
SubjectTerms Ablation
Adipocytes
Analysis
Animals
Biological and medical sciences
Blotting, Western
Body composition
Calorimetry
Cellular proteins
Diabetes
Diabetes. Impaired glucose tolerance
Diet
Diet, High-Fat - adverse effects
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzymes
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty acids
Glucose
Glucose Tolerance Test
Homeostasis
Hyperglycemia
Insulin resistance
Insulin Resistance - genetics
Insulin Resistance - physiology
Kinases
Medical sciences
Metabolic diseases
Metabolism
Mice
Obesity
Obesity - etiology
Obesity - genetics
Obesity - surgery
Original Research
Oxidation
Physiological aspects
Receptors, Steroid - genetics
Receptors, Steroid - metabolism
Title PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice
URI https://www.ncbi.nlm.nih.gov/pubmed/23349477
https://www.proquest.com/docview/1426056951
https://www.proquest.com/docview/1355480011
https://pubmed.ncbi.nlm.nih.gov/PMC3661619
Volume 62
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELZgkxASQvwmMCqD0ODFWmIntveEStkYiI6pYqJvVuw4Y9KUFtL-_9zFbragipdKsa9OfL7Y3znn7wh562HJrZS0zOe5ZbkoFbNWKAaLRVppXWnR0S5OT-XJef51Xszjhlsbwyo3c2I3UVcLh3vkBxlSqRcSAMGH5W-GWaPw62pMoXGb7CJ1GVq1mvcOVwrgPBxByTjScKrALMTh9geVxbIUc4TfWI_irHxvWbagoTqkttiGPf8NobyxJh0_IPcjmKTjMPoPyS3fPCJ3pvFz-WPy82w-o2Mbwt3o-AqPkiO2pJ8u_Yph1g7nK1o2FUX2aWiExjwBXdmXEKZOZ1CEGNJ5CldTmFmekPPjox-TExYzKTAnlVwxX-aWO-4AnNaVT11dFxjbminpC2F1WWXg5eVOcNCKV05rm4NnWJRc2tJVXIqnZKdZNP45od7LvBaqFhqZ250ua80F3MWn9hBGPU_I-40-jYs045jt4sqAu4GqN6h6g6pPyJtedBm4NbYJ7eOgGOSqaDAYxoUNFQP9m3w3YwH4sygAlkJrQ8GLct22Rn_-NhB6F4XqBTyVK-MhBOgb8mANJPcHkheBBXyb4N5AEF5PN6geDayp7ylXOaDdQwn_35iXifNHa66tPSGv-2psGmPiGr9YgwxCRY2YPiHPgjVeNy6QdkiphKiBnfYCyCo-rGkuf3Xs4gIQG3jVL_7_WC_JXR4Sg7A02yM7qz9r_wrg2cqOuncQfvUkG5Hdj0enZ7O_JnA5cA
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLXGkGASQnyOwBgGwcZLtMR2Yu8BoapjtKwdaNpE30zsOGPSlBbSCvGn-I3cG6ftgire9ljnxI3ta_vc5PpcQl472HJzmZrQCWFCwTMZGsNlCJtFlCuVK17LLg6P096Z-DRKRmvkz_wsDIZVztfEeqHOxxbfke_FKKWepEAI3k9-hJg1Cr-uzlNoeLM4cr9_gctWvesfwPi-Yezww2m3FzZZBUKbynQaukwYZpkFolbkLrJFkWCcZyxTl3CjsjwGj0dYzkzMnLRKGQFeUpKx1GQ2ZymHem-QmwIagTNKdZchJeAM-CMvMUPZT-mVjBgg93KDZRHmJL-y_zW7wJ1JVsGIFD6Vxiqu-2_I5pU98PAeuduQV9rx1nafrLnyAbk1bD7PPyRfv4xOaMf48DraucSj68hl6cGFm4aYJcS6nGZlTlHtGiqhTV6Cuqzvw-LpCRQhZ7WOwq8hrGSPyNm19PFjsl6OS_eEUOdSUXBZcIVK8VZlhWIc_sVFZh-sTATk7bw_tW1kzTG7xqUG9wa7XmPXa-z6gLxaQCdey2MVaAcHRaM2RonBN9a_wNHQvu5n3eHAd5MEaDDU1gaeZ7Oq0urjoAXabUDFGJ7KZs2hB2gb6m61kDst5LlXHV8F3GoBYTmwrcvbLWtatJRJAex6P4X75-alm_Wq0svZFZCXi8tYNcbglW48AwxSU4U-REA2vTUuK-cocyRlQGTLThcAVDFvXykvvtdq5hwYInjxT___WC_I7d7pcKAH_eOjZ2SD-aQkYRRvkfXpz5l7DtRwarbr-UjJt-teAP4C8Px0Lg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLXGkCYkhPgmMIZBMHiJmthJ7D0gVLWUla1jmpjWN2M7zpg0pYW0Qvw1fh33xmm7oIq3PdY5cWP72j43uT6XkNcOttxcZCZ0SWLChGsRGsNFCJtFlEuZS17LLo6Osv3T5PM4HW-QP4uzMBhWuVgT64U6n1h8R96JUUo9zYAQdIomLOK4P_gw_RFiBin80rpIp-FN5MD9_gXuW_V-2IexfsPY4OPX3n7YZBgIbSayWeh0YphlFkhbkbvIFkWKMZ-xyFzKjdR5DN5PYjkzMXPCSmkS8JhSzTKjbc4yDvXeIDcFFxLnmOytwkvAMfDHX2KGEqDCqxoxaHonN1gWYX7yK3thsyPcnuoKRqfwaTXW8d5_wzev7IeDu-ROQ2Rp11vePbLhyvtka9R8qn9Azo7HJ7RrfKgd7V7iMXbktbR_4WYhZgyxLqe6zCkqX0MltMlRUJcNfYg8PYEi5K_WUfg1glXtITm9lj5-RDbLSemeEOpclhRcFFyiaryVupCMw7-4yOyBxSUBebfoT2UbiXPMtHGpwNXBrlfY9Qq7PiCvltCp1_VYB9rFQVGok1GixVn_MkdB-3pfVJcD901ToMRQWxt4rudVpeSnwxbobQMqJvBUVjcHIKBtqMHVQu62kOdegXwdcLsFhKXBti7vtKxp2VImEmDaexncvzAv1axdlVrNtIC8XF7GqjEer3STOWCQpkr0JwLy2FvjqnKOkkdCBES07HQJQEXz9pXy4nutbM6BLYJH__T_j_WCbMHUV4fDo4Nn5Bbz-UnCKN4mm7Ofc_ccWOLM7NTTkZJv1z3__wJ093hk
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=PXR+ablation+alleviates+diet%2C+induced+and+genetic+obesity+and+insulin+resistance+in+mice&rft.jtitle=Diabetes+%28New+York%2C+N.Y.%29&rft.au=He%2C+Jinhan&rft.au=Gao%2C+Jie&rft.au=Xu%2C+Meishu&rft.au=Ren%2C+Songrong&rft.date=2013-06-01&rft.pub=American+Diabetes+Association&rft.issn=0012-1797&rft.volume=62&rft.issue=6&rft.spage=1876&rft_id=info:doi/10.2337%2Fdb12-1039&rft.externalDocID=A332655565
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-1797&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-1797&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-1797&client=summon