Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/NFkB pathway

• Published in: Biological research Vol. 51; no. 1; pp. 17 - 10
• Main Authors: Moniruzzaman, Mahammed, Ghosal, Indranath, Das, Debjit, Chakraborty, Suman Bhusan
• Format: Journal Article
• Language: English
• Published: Santiago BioMed Central Ltd 11.06.2018; BioMed Central; Sociedad de Biología de Chile; BMC
• Subjects: AKT protein; Analysis; Antioxidants; BIOLOGY; Catalase; Cellular signal transduction; Enzymes; Extracellular signal-regulated kinase; Fish; Free radicals; Gene expression; Glutathione; Health aspects; Heat shock proteins; Hepatocytes; Hsp70 protein; Hsp90 protein; Hydrogen peroxide; Kinases; Laboratory animals; Liver; Liver diseases; Malondialdehyde; Melatonin; NF-κB protein; Oxidation; Oxidative stress; Phosphorylation; Physiology; Pineal gland; Reactive oxygen species; Rodents; Signal transduction; Stress response; Studies; Superoxide dismutase; Western blotting; Heat shock proteins; Oxidative stress; Fish; Melatonin; Hepatocytes

Background Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative damage in different vertebrates. Aim of the current communication is to evaluate the...