Markers of Glutamate Synaptic Transmission and Plasticity Are Increased in the Anterior Cingulate Cortex in Bipolar Disorder

• Published in: Biological psychiatry (1969) Vol. 67; no. 11; pp. 1010 - 1016
• Main Authors: Eastwood, Sharon L., Harrison, Paul J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2010; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Analysis of Variance; Biological and medical sciences; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Bipolar disorders; Female; Functional Laterality - physiology; Gene expression; Genotype; Glutamic Acid - genetics; Glutamic Acid - metabolism; Glycoproteins - genetics; Glycoproteins - metabolism; GPI-Linked Proteins; Gyrus Cinguli - metabolism; Humans; In Situ Hybridization; laminets; Male; Medical sciences; Middle Aged; Mood disorders; mRNA; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Netrins; Neuronal Plasticity - physiology; Neurons - metabolism; Presynaptic Terminals - metabolism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reverse Transcriptase Polymerase Chain Reaction; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Synaptic Transmission - physiology; Vesicular Glutamate Transport Protein 1 - genetics; Vesicular Glutamate Transport Protein 1 - metabolism; vesicular glutamate transporter; laminets; mRNA; schizophrenia; Gene expression; vesicular glutamate transporter; netrins; Mood disorder; Central nervous system; Schizophrenia; Bipolar disorder; Genetic determinism; Encephalon; Psychosis; Cingulate cortex; Synaptic transmission; Synaptic plasticity; Genetics; VGLUT glutamate transporter; Glutamatergic transmission

Cortical glutamate levels are elevated in bipolar disorder, but the interpretation of this increase is unclear because glutamate has metabolic as well as neurotransmitter roles. We investigated this by measuring vesicular glutamate transporter 1 (VGluT1) expression, which reflects activity at glutam...