Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression

• Published in: Biological psychiatry (1969) Vol. 68; no. 6; pp. 560 - 567
• Main Authors: Versace, Amelia, Almeida, Jorge R.C., Quevedo, Karina, Thompson, Wesley K., Terwilliger, Robert A., Hassel, Stefanie, Kupfer, David J., Phillips, Mary L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.09.2010; Elsevier
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Anisotropy; Biological and medical sciences; Bipolar Disorder - diagnosis; Bipolar Disorder - pathology; Bipolar disorders; Brain - pathology; Depression; Depressive Disorder - diagnosis; Depressive Disorder - pathology; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging - methods; diffusion tensor imaging; Female; Humans; inferior longitudinal fasciculus; Male; Medical sciences; Middle Aged; Mood disorders; Nerve Fibers, Myelinated - pathology; Neural Pathways - pathology; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; superior longitudinal fasciculus; uncinate fasciculus; uncinate fasciculus; Depression; diffusion tensor imaging; superior longitudinal fasciculus; inferior longitudinal fasciculus; mood disorders; Mood disorder; Orbitofrontal cortex; Corticocortical connection; Central nervous system; Bipolar disorder; Nuclear magnetic resonance imaging; White matter; Encephalon; Diffusion tensor imaging; Medical imagery

The absence of pathophysiologically relevant diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. We employed a three-way analysis of covar...