Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity

• Published in: Diabetes (New York, N.Y.) Vol. 61; no. 8; pp. 1986 - 1993
• Main Authors: Arner, Erik, Mejhert, Niklas, Kulyté, Agné, Balwierz, Piotr J., Pachkov, Mikhail, Cormont, Mireille, Lorente-Cebrián, Silvia, Ehrlund, Anna, Laurencikiene, Jurga, Hedén, Per, Dahlman-Wright, Karin, Tanti, Jean-François, Hayashizaki, Yoshihide, Rydén, Mikael, Dahlman, Ingrid, van Nimwegen, Erik, Daub, Carsten O., Arner, Peter
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2012
• Subjects: Adipocytes; Adipocytes - metabolism; Adipose Tissue, White - metabolism; Adipose tissues; Biological and medical sciences; Body fat; Cell Line; Chemokine CCL2 - biosynthesis; Chemokines; Complications and side effects; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gene expression; Genetic aspects; Humans; Inflammation; Inflammation - metabolism; Insulin resistance; Insulin Resistance - physiology; Ligands; Ligands (Biochemistry); Macrophages - metabolism; Medical sciences; Metabolic diseases; MicroRNAs; MicroRNAs - metabolism; Obesity; Obesity - metabolism; Obesity Studies; Physiological aspects; Proteins; Risk factors; Transcription factors; Sweden; Endocrinopathy; Human; Obesity; Adipose tissue; Diabetes mellitus; Nutrition disorder; Nutritional status

In obesity, white adipose tissue (WAT) inflammation is linked to insulin resistance. Increased adipocyte chemokine (C-C motif) ligand 2 (CCL2) secretion may initiate adipose inflammation by attracting the migration of inflammatory cells into the tissue. Using an unbiased approach, we identified adip...