Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion

• Published in: NeuroImage (Orlando, Fla.) Vol. 59; no. 3; pp. 2142 - 2154
• Main Authors: Power, Jonathan D., Barnes, Kelly A., Snyder, Abraham Z., Schlaggar, Bradley L., Petersen, Steven E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2012; Elsevier Limited
• Subjects: Algorithms; Brain; Brain - anatomy & histology; Cohort Studies; Computer programs; Correlation; Dealing; Estimates; fcMRI; fMRI; Head Movements; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Motion; Movement; Movements; Network; Noise; Oxygen - blood; Platforms; Regression; Resting state; Software; Statistics; fMRI; Motion; Resting state; Movement; Noise; Network; fcMRI; Artifact

Here, we demonstrate that subject motion produces substantial changes in the timecourses of resting state functional connectivity MRI (rs-fcMRI) data despite compensatory spatial registration and regression of motion estimates from the data. These changes cause systematic but spurious correlation st...