Integrative genomics identifies LMO1 as a neuroblastoma oncogene

• Published in: Nature (London) Vol. 469; no. 7329; pp. 216 - 220
• Main Authors: Wang, Kai, Diskin, Sharon J., Zhang, Haitao, Attiyeh, Edward F., Winter, Cynthia, Hou, Cuiping, Schnepp, Robert W., Diamond, Maura, Bosse, Kristopher, Mayes, Patrick A., Glessner, Joseph, Kim, Cecilia, Frackelton, Edward, Garris, Maria, Wang, Qun, Glaberson, Wendy, Chiavacci, Rosetta, Le Nguyen, Jagannathan, Jayanti, Saeki, Norihisa, Sasaki, Hiroki, Grant, Struan F. A., Iolascon, Achille, Mosse, Yael P., Cole, Kristina A., Li, Hongzhe, Devoto, Marcella, McGrady, Patrick W., London, Wendy B., Capasso, Mario, Rahman, Nazneen, Hakonarson, Hakon, Maris, John M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.01.2011; Nature Publishing Group
• Subjects: 631/208/727/2000; 631/378/1689/1690; 631/67/395; Alleles; Biological and medical sciences; Biomarkers; Cell Line, Tumor; Cell physiology; Cell Proliferation; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Children & youth; Chromosomes, Human, Pair 11 - genetics; Disease Progression; DNA Copy Number Variations - genetics; DNA-Binding Proteins - genetics; Europe - ethnology; Fundamental and applied biological sciences. Psychology; Gene Duplication - genetics; Gene Expression Regulation, Neoplastic - genetics; Gene loci; Gene therapy; Genetic aspects; Genetic Predisposition to Disease - genetics; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human - genetics; Genome-Wide Association Study; Genomics; Genotype; Genotype & phenotype; Health risk assessment; Human; Humanities and Social Sciences; Humans; Identification and classification; Kinases; letter; LIM Domain Proteins; Molecular and cellular biology; multidisciplinary; Neuroblastoma; Neuroblastoma - genetics; Neuroblastoma - pathology; Odds Ratio; Oncogenes; Oncogenes - genetics; Phenotype; Polymorphism, Single Nucleotide - genetics; Population genetics, reproduction patterns; Risk factors; Science; Science (multidisciplinary); Survival Rate; Transcription Factors - genetics; Europe; United States; Human; Identification; Neuroblastoma; Onc gene; Population genetics; Genomics

GWAS identifies oncogene A genome-wide association study (GWAS) has shown that single nucleotide variants within the LMO1 locus are associated with inherited susceptibility to neuroblastoma, a childhood cancer of the sympathetic nervous system. LMO1 encodes a transcriptional regulator previously lin...