The Oral Minimal Model Method

• Published in: Diabetes (New York, N.Y.) Vol. 63; no. 4; pp. 1203 - 1213
• Main Authors: Cobelli, Claudio, Dalla Man, Chiara, Toffolo, Gianna, Basu, Rita, Vella, Adrian, Rizza, Robert
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.2014
• Subjects: Adolescent; Biological and medical sciences; Blood Glucose - metabolism; C-Peptide - metabolism; Child; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Food; Glucose; Glucose - metabolism; Glucose Clamp Technique; Glucose Tolerance Test; Human subjects; Humans; Insulin; Insulin - metabolism; Insulin - physiology; Insulin Resistance - physiology; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - physiology; Liver - metabolism; Mathematical models; Medical sciences; Metabolism; Methodology Review; Models, Biological; Pancreatic beta cells; Physiology; Postprandial Period - physiology; Testing; Endocrinopathy; Diabetes mellitus; Models

The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We review the oral minimal method (i.e., models that allow the estimation of insulin sensitivity, β-cell responsivity, and hepa...