Age‐related rhesus macaque models of COVID‐19

• Published in: Animal models and experimental medicine Vol. 3; no. 1; pp. 93 - 97
• Main Authors: Yu, Pin, Qi, Feifei, Xu, Yanfeng, Li, Fengdi, Liu, Peipei, Liu, Jiayi, Bao, Linlin, Deng, Wei, Gao, Hong, Xiang, Zhiguang, Xiao, Chong, Lv, Qi, Gong, Shuran, Liu, Jiangning, Song, Zhiqi, Qu, Yajin, Xue, Jing, Wei, Qiang, Liu, Mingya, Wang, Guanpeng, Wang, Shunyi, Yu, Haisheng, Liu, Xing, Huang, Baoying, Wang, Wenling, Zhao, Li, Wang, Huijuan, Ye, Fei, Zhou, Weimin, Zhen, Wei, Han, Jun, Wu, Guizhen, Jin, Qi, Wang, Jianwei, Tan, Wenjie, Qin, Chuan
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2020; John Wiley and Sons Inc; Wiley
• Subjects: Alveoli; Animal models; animals; Antigens; Blood; chest; China; Coronaviruses; COVID-19; COVID-19 infection; death; Drug development; Edema; Epithelial cells; epithelium; Genomes; histopathology; Immune response; inflammation; Laboratory animals; lungs; Lymphocytes; Macaca mulatta; Macrophages; medicine; Monkeys & apes; pathogenicity; Pneumonia; Public health; Replication; rhesus macaque model; SARS‐CoV‐2; Septum; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2; Short Communication; Short Communications; therapeutics; virus replication; Viruses; X-radiation; China; pathogenicity; rhesus macaque model; pneumonia; SARS‐CoV‐2

Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need...