Age‐related rhesus macaque models of COVID‐19
Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need...
Saved in:
| Published in | Animal models and experimental medicine Vol. 3; no. 1; pp. 93 - 97 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
John Wiley & Sons, Inc
01.03.2020
John Wiley and Sons Inc Wiley |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Background
Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models.
Methods
Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response.
Results
Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages.
Conclusion
SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection. |
|---|---|
| AbstractList | Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.
Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2, and then analyzed by clinical signs, viral replication, chest X-ray, histopathological changes and immune response.
Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages.
SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. BackgroundSince December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models.MethodsThree 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response.ResultsViral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages.ConclusionSARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection. Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.BACKGROUNDSince December 2019, an outbreak of the Corona Virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2, and then analyzed by clinical signs, viral replication, chest X-ray, histopathological changes and immune response.METHODSThree 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2, and then analyzed by clinical signs, viral replication, chest X-ray, histopathological changes and immune response.Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages.RESULTSViral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages.SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.CONCLUSIONSARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. Abstract Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. Methods Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. Results Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. Conclusion SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection. Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. Methods Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. Results Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. Conclusion SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection. BACKGROUND: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. METHODS: Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. RESULTS: Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. CONCLUSION: SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection. |
| Author | Wang, Guanpeng Tan, Wenjie Liu, Peipei Jin, Qi Wang, Jianwei Qin, Chuan Liu, Mingya Yu, Haisheng Liu, Xing Gao, Hong Liu, Jiangning Lv, Qi Ye, Fei Wang, Wenling Huang, Baoying Han, Jun Deng, Wei Xiang, Zhiguang Wang, Shunyi Zhao, Li Gong, Shuran Yu, Pin Xu, Yanfeng Xiao, Chong Wang, Huijuan Qi, Feifei Zhou, Weimin Xue, Jing Wu, Guizhen Wei, Qiang Bao, Linlin Song, Zhiqi Li, Fengdi Qu, Yajin Liu, Jiayi Zhen, Wei |
| AuthorAffiliation | 2 MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China 3 Department of Radiology Bejing Anzhen Hospital Capital Medical University Beijing China 4 Institute of Pathogen Biology Chinese Academy of Medical Sciences Beijing China 1 Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China 5 Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China |
| AuthorAffiliation_xml | – name: 2 MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China – name: 5 Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China – name: 1 Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China – name: 4 Institute of Pathogen Biology Chinese Academy of Medical Sciences Beijing China – name: 3 Department of Radiology Bejing Anzhen Hospital Capital Medical University Beijing China |
| Author_xml | – sequence: 1 givenname: Pin surname: Yu fullname: Yu, Pin organization: Peking Union Medical College – sequence: 2 givenname: Feifei surname: Qi fullname: Qi, Feifei organization: Peking Union Medical College – sequence: 3 givenname: Yanfeng surname: Xu fullname: Xu, Yanfeng organization: Peking Union Medical College – sequence: 4 givenname: Fengdi surname: Li fullname: Li, Fengdi organization: Peking Union Medical College – sequence: 5 givenname: Peipei surname: Liu fullname: Liu, Peipei organization: China CDC – sequence: 6 givenname: Jiayi surname: Liu fullname: Liu, Jiayi organization: Capital Medical University – sequence: 7 givenname: Linlin surname: Bao fullname: Bao, Linlin organization: Peking Union Medical College – sequence: 8 givenname: Wei surname: Deng fullname: Deng, Wei organization: Peking Union Medical College – sequence: 9 givenname: Hong surname: Gao fullname: Gao, Hong organization: Peking Union Medical College – sequence: 10 givenname: Zhiguang surname: Xiang fullname: Xiang, Zhiguang organization: Peking Union Medical College – sequence: 11 givenname: Chong surname: Xiao fullname: Xiao, Chong organization: Peking Union Medical College – sequence: 12 givenname: Qi surname: Lv fullname: Lv, Qi organization: Peking Union Medical College – sequence: 13 givenname: Shuran surname: Gong fullname: Gong, Shuran organization: Peking Union Medical College – sequence: 14 givenname: Jiangning surname: Liu fullname: Liu, Jiangning organization: Peking Union Medical College – sequence: 15 givenname: Zhiqi surname: Song fullname: Song, Zhiqi organization: Peking Union Medical College – sequence: 16 givenname: Yajin surname: Qu fullname: Qu, Yajin organization: Peking Union Medical College – sequence: 17 givenname: Jing surname: Xue fullname: Xue, Jing organization: Peking Union Medical College – sequence: 18 givenname: Qiang surname: Wei fullname: Wei, Qiang organization: Peking Union Medical College – sequence: 19 givenname: Mingya surname: Liu fullname: Liu, Mingya organization: Peking Union Medical College – sequence: 20 givenname: Guanpeng surname: Wang fullname: Wang, Guanpeng organization: Peking Union Medical College – sequence: 21 givenname: Shunyi surname: Wang fullname: Wang, Shunyi organization: Peking Union Medical College – sequence: 22 givenname: Haisheng surname: Yu fullname: Yu, Haisheng organization: Peking Union Medical College – sequence: 23 givenname: Xing surname: Liu fullname: Liu, Xing organization: Peking Union Medical College – sequence: 24 givenname: Baoying surname: Huang fullname: Huang, Baoying organization: China CDC – sequence: 25 givenname: Wenling surname: Wang fullname: Wang, Wenling organization: China CDC – sequence: 26 givenname: Li surname: Zhao fullname: Zhao, Li organization: China CDC – sequence: 27 givenname: Huijuan surname: Wang fullname: Wang, Huijuan organization: China CDC – sequence: 28 givenname: Fei surname: Ye fullname: Ye, Fei organization: China CDC – sequence: 29 givenname: Weimin surname: Zhou fullname: Zhou, Weimin organization: China CDC – sequence: 30 givenname: Wei surname: Zhen fullname: Zhen, Wei organization: China CDC – sequence: 31 givenname: Jun surname: Han fullname: Han, Jun organization: China CDC – sequence: 32 givenname: Guizhen surname: Wu fullname: Wu, Guizhen organization: China CDC – sequence: 33 givenname: Qi surname: Jin fullname: Jin, Qi organization: Chinese Academy of Medical Sciences – sequence: 34 givenname: Jianwei surname: Wang fullname: Wang, Jianwei organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 35 givenname: Wenjie surname: Tan fullname: Tan, Wenjie email: tanwj@ivdc.chinacdc.cn organization: China CDC – sequence: 36 givenname: Chuan orcidid: 0000-0002-6261-1232 surname: Qin fullname: Qin, Chuan email: qinchuan@pumc.edu.cn organization: Peking Union Medical College |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32318665$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFks1qFTEYhoNUbK3deAEy4EaEU_M3-dkIh2PVA5VuituQk3w5ncPMpCYzle68BK_RKzHTqaUtoquE5PmevEm-52ivjz0g9JLgY4IxfWc7oMeEEqyeoANaS7GgWNd79-b76CjnHS4wJoxj8QztM8qIEqI-QGS5hV8_fiZo7QC-SheQx1x11tlvI1Rd9NDmKoZqdfZ1_aGARL9AT4NtMxzdjofo_OPJ-erz4vTs03q1PF04IYVayBpLjJlVQgXHhcNB-5pyHkBwq-qSxVMSwkYpgIB1kLW32klquRKEATtE61nro92Zy9R0Nl2baBtzsxDT1tg0NK4FQxSjyhGy8cxzzKjmlmvO1YZ752qwxfV-dl2Omw68g35Itn0gfbjTNxdmG6-MJEJSxovgza0gxfIueTBdkx20re0hjtlQWTLIWkj9f5RpVmuihSzo60foLo6pL486UYThcvpEvbof_i71nz8swNsZcCnmnCDcIQSbqUfM1CPmpkcKjB_Brhns0MTp4k379xIyl3xvWrj-h9wsv5zQueY3uDXK2Q |
| CitedBy_id | crossref_primary_10_1016_j_celrep_2022_111573 crossref_primary_10_1016_j_virusres_2022_199024 crossref_primary_10_1038_s41392_021_00734_w crossref_primary_10_1152_physrev_00046_2020 crossref_primary_10_1371_journal_ppat_1008820 crossref_primary_10_1590_0074_02760220239 crossref_primary_10_1177_03009858211071016 crossref_primary_10_1039_D0AN01686A crossref_primary_10_1016_j_ebiom_2021_103769 crossref_primary_10_1371_journal_ppat_1008949 crossref_primary_10_3390_ani13071223 crossref_primary_10_1073_pnas_2010817117 crossref_primary_10_1177_11786302221107786 crossref_primary_10_1002_ame2_12257 crossref_primary_10_5501_wjv_v11_i1_40 crossref_primary_10_1093_ilar_ilab007 crossref_primary_10_1016_j_coviro_2021_03_009 crossref_primary_10_1038_s41423_023_01122_w crossref_primary_10_3389_fimmu_2022_821664 crossref_primary_10_3389_fimmu_2021_722181 crossref_primary_10_1016_j_amjms_2020_08_017 crossref_primary_10_1080_22221751_2023_2178242 crossref_primary_10_1186_s12985_020_01396_w crossref_primary_10_1016_j_bsheal_2022_09_001 crossref_primary_10_1111_xen_12651 crossref_primary_10_1016_S2666_5247_20_30089_6 crossref_primary_10_3389_fimmu_2021_765349 crossref_primary_10_3390_ani12030378 crossref_primary_10_1038_s42003_020_01370_w crossref_primary_10_1007_s11259_021_09787_2 crossref_primary_10_1093_cid_ciab903 crossref_primary_10_1002_ame2_12127 crossref_primary_10_1080_02786826_2020_1796921 crossref_primary_10_3390_pathogens12010020 crossref_primary_10_1172_jci_insight_153165 crossref_primary_10_3748_wjg_v26_i31_4694 crossref_primary_10_2478_ebtj_2021_0002 crossref_primary_10_1146_annurev_pathol_052620_121224 crossref_primary_10_3389_fgene_2020_607479 crossref_primary_10_3389_fimmu_2024_1440314 crossref_primary_10_1111_bcp_14686 crossref_primary_10_1126_sciimmunol_abo0535 crossref_primary_10_1172_JCI146031 crossref_primary_10_3390_hygiene1010001 crossref_primary_10_1016_j_antiviral_2022_105492 crossref_primary_10_1002_ajp_23161 crossref_primary_10_1002_ame2_12156 crossref_primary_10_1002_ame2_12278 crossref_primary_10_1021_acsptsci_3c00127 crossref_primary_10_4049_jimmunol_2000922 crossref_primary_10_1186_s12985_020_01416_9 crossref_primary_10_1016_j_jddst_2022_103131 crossref_primary_10_1080_07853890_2022_2031274 crossref_primary_10_3947_ic_2020_52_2_154 crossref_primary_10_3390_v15040862 crossref_primary_10_1093_nsr_nwaa291 crossref_primary_10_1016_j_tim_2023_07_002 crossref_primary_10_1016_j_ebiom_2021_103291 crossref_primary_10_1177_01926233211072767 crossref_primary_10_1038_s41421_024_00734_4 crossref_primary_10_1038_s41392_021_00818_7 crossref_primary_10_1016_j_celrep_2020_108488 crossref_primary_10_1093_infdis_jiab104 crossref_primary_10_1101_gr_278968_124 crossref_primary_10_1371_journal_ppat_1008902 crossref_primary_10_1128_mBio_01503_21 crossref_primary_10_14336_AD_2020_0601 crossref_primary_10_1038_s41467_021_27717_3 crossref_primary_10_1002_ajp_23340 crossref_primary_10_1038_s41598_023_30473_7 crossref_primary_10_1038_s41392_024_01796_2 crossref_primary_10_1002_ame2_12211 crossref_primary_10_1111_tbed_13907 crossref_primary_10_1002_prp2_653 crossref_primary_10_1080_21645515_2020_1807802 crossref_primary_10_1007_s12195_020_00638_9 crossref_primary_10_1186_s12985_023_02031_0 crossref_primary_10_1038_s41598_024_80474_3 crossref_primary_10_1002_zoo_21576 crossref_primary_10_1002_jmv_29640 crossref_primary_10_1126_scitranslmed_abe0948 crossref_primary_10_1016_j_coviro_2023_101375 crossref_primary_10_1111_mam_12225 crossref_primary_10_1016_j_it_2020_11_002 crossref_primary_10_1016_j_pecon_2020_09_008 crossref_primary_10_1093_femsre_fuac042 crossref_primary_10_1016_j_virusres_2021_198473 crossref_primary_10_3389_fimmu_2023_1223260 crossref_primary_10_1016_j_envres_2020_110293 crossref_primary_10_1111_jmp_12483 crossref_primary_10_4110_in_2021_21_e12 crossref_primary_10_3390_antiox10091440 crossref_primary_10_1080_08958378_2024_2412685 crossref_primary_10_1038_s41467_025_58173_y crossref_primary_10_1080_14760584_2020_1813574 crossref_primary_10_1038_s41586_020_2787_6 crossref_primary_10_1038_s41598_023_29588_8 crossref_primary_10_1556_650_2021_32117 crossref_primary_10_1016_j_healun_2021_04_017 crossref_primary_10_3390_v13030379 crossref_primary_10_1016_j_ccc_2021_05_004 crossref_primary_10_1002_rmv_2196 crossref_primary_10_1038_s41579_020_00459_7 crossref_primary_10_1371_journal_pone_0235106 crossref_primary_10_3389_fmicb_2022_907406 crossref_primary_10_1038_s41598_024_80498_9 crossref_primary_10_3389_fmicb_2021_770935 crossref_primary_10_30802_AALAS_CM_20_000119 crossref_primary_10_1038_s41467_020_18149_6 crossref_primary_10_1126_science_abc5343 crossref_primary_10_3389_fimmu_2020_02163 crossref_primary_10_3389_fimmu_2020_570063 crossref_primary_10_2139_ssrn_3578773 crossref_primary_10_3390_vaccines12101099 crossref_primary_10_1096_fj_202001808R crossref_primary_10_3390_vaccines9040391 crossref_primary_10_1016_j_it_2020_10_004 crossref_primary_10_1371_journal_ppat_1010741 crossref_primary_10_1016_j_cell_2020_06_008 crossref_primary_10_1371_journal_ppat_1009758 crossref_primary_10_36233_0507_4088_293 crossref_primary_10_1038_s41385_020_00340_z crossref_primary_10_1002_mco2_98 crossref_primary_10_3390_vaccines9101082 crossref_primary_10_1093_gbe_evac100 crossref_primary_10_1098_rstb_2022_0462 crossref_primary_10_1371_journal_ppat_1009195 crossref_primary_10_1371_journal_ppat_1010618 crossref_primary_10_4110_in_2021_21_e1 crossref_primary_10_2174_1381612826666201118112203 crossref_primary_10_1371_journal_ppat_1009865 crossref_primary_10_1080_23144599_2023_2222981 crossref_primary_10_1126_scitranslmed_abf1906 crossref_primary_10_1016_j_molmed_2021_12_001 crossref_primary_10_1124_pharmrev_123_000967 crossref_primary_10_1172_JCI144115 crossref_primary_10_1111_bph_15143 crossref_primary_10_3390_v12070713 crossref_primary_10_1038_s41392_022_00891_6 crossref_primary_10_37349_ei_2021_00030 crossref_primary_10_3389_fimmu_2022_853522 crossref_primary_10_1038_s41598_022_08431_6 crossref_primary_10_3390_vaccines9050520 crossref_primary_10_1007_s00894_023_05536_1 crossref_primary_10_1177_03009858221079665 crossref_primary_10_3390_v13101993 crossref_primary_10_1126_scitranslmed_abd1525 crossref_primary_10_1038_s41590_020_00835_8 crossref_primary_10_4110_in_2020_20_e28 crossref_primary_10_1038_s41598_020_72563_w crossref_primary_10_3389_fimmu_2020_573662 crossref_primary_10_1152_physrev_00035_2020 crossref_primary_10_1016_j_vaccine_2020_05_064 crossref_primary_10_1128_spectrum_02263_22 crossref_primary_10_3389_fmicb_2021_626553 crossref_primary_10_3390_v14020418 crossref_primary_10_1016_j_biochi_2021_06_005 crossref_primary_10_3389_fphar_2020_600369 crossref_primary_10_3389_fmed_2021_644678 crossref_primary_10_3389_fmicb_2020_618891 crossref_primary_10_3390_v12080880 crossref_primary_10_1016_j_cell_2020_06_010 crossref_primary_10_1016_j_cmpb_2024_108354 crossref_primary_10_33611_trs_2021_027 crossref_primary_10_1093_bib_bbaa329 crossref_primary_10_1007_s12250_020_00252_z crossref_primary_10_1165_rcmb_2020_0280LE crossref_primary_10_1038_s41422_021_00523_8 crossref_primary_10_1002_iub_2379 crossref_primary_10_3389_fimmu_2020_01817 crossref_primary_10_4103_ijmr_IJMR_3215_20 crossref_primary_10_3389_fcell_2023_1238027 crossref_primary_10_1111_tbed_13978 crossref_primary_10_1126_science_abc1932 crossref_primary_10_1186_s13578_021_00621_5 crossref_primary_10_1038_s41392_020_00269_6 crossref_primary_10_1186_s13054_020_03304_8 crossref_primary_10_3389_fvets_2020_596391 crossref_primary_10_1007_s13337_020_00637_4 crossref_primary_10_1128_JVI_00083_21 crossref_primary_10_1515_med_2023_0822 crossref_primary_10_1097_SHK_0000000000001565 crossref_primary_10_1111_tbed_13861 crossref_primary_10_1016_j_molimm_2021_04_010 crossref_primary_10_1073_pnas_2104847118 crossref_primary_10_1016_j_cell_2021_02_029 crossref_primary_10_1007_s11357_020_00213_0 crossref_primary_10_1038_s41421_024_00733_5 crossref_primary_10_1080_22221751_2022_2026741 crossref_primary_10_3390_vaccines9010011 crossref_primary_10_1111_bph_15094 crossref_primary_10_1016_j_virol_2020_12_013 crossref_primary_10_1080_21505594_2024_2316438 crossref_primary_10_1186_s13578_021_00567_8 crossref_primary_10_3390_biomedicines11113002 crossref_primary_10_3390_vaccines9080886 crossref_primary_10_1126_sciadv_adj1736 crossref_primary_10_1177_03009858221092015 crossref_primary_10_1093_ilar_ilab010 crossref_primary_10_3390_v12070779 crossref_primary_10_1016_j_chom_2020_09_016 crossref_primary_10_1007_s13238_022_00915_5 crossref_primary_10_1016_j_thromres_2021_08_007 crossref_primary_10_12688_openreseurope_14375_1 crossref_primary_10_2174_2666796701999200701132336 crossref_primary_10_4103_ijmr_IJMR_4431_20 crossref_primary_10_14202_vetworld_2021_2817_2826 crossref_primary_10_2174_1389200221666200711160440 crossref_primary_10_1038_s41598_021_92388_5 crossref_primary_10_1186_s13020_020_00393_z crossref_primary_10_3390_pathogens9070529 |
| Cites_doi | 10.1056/NEJMoa2001017 10.1056/NEJMoa2001316 10.1016/S0140-6736(20)30251-8 10.1002/path.1769 10.1016/S0140-6736(20)30183-5 10.1007/s11427-020-1637-5 |
| ContentType | Journal Article |
| Copyright | 2020 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2020 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences – notice: 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. – notice: 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION NPM 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU COVID DWQXO GNUQQ HCIFZ LK8 M7P PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS 7X8 7S9 L.6 5PM DOA |
| DOI | 10.1002/ame2.12108 |
| DatabaseName | Wiley Online Library Open Access CrossRef PubMed ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Database Suite (ProQuest) Natural Science Collection ProQuest One Coronavirus Research Database ProQuest Central Korea ProQuest Central Student ProQuest SciTech Premium Collection Biological Sciences Biological Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Biological Science Collection ProQuest Central Essentials ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | PubMed Publicly Available Content Database MEDLINE - Academic AGRICOLA |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health Medicine |
| DocumentTitleAlternate | YU et al |
| EISSN | 2576-2095 |
| EndPage | 97 |
| ExternalDocumentID | oai_doaj_org_article_18328c11bd3d403294a49448b4dcc5ea PMC7167234 32318665 10_1002_ame2_12108 AME212108 |
| Genre | shortCommunication Journal Article |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GrantInformation_xml | – fundername: National Key Research and Development Programme of China funderid: 2016YFD0500301; 2020YFC0840800; 2020YFC0840900 – fundername: CAMS initiative for Innovative Medicine of China funderid: 2016‐I2M‐2‐006 – fundername: the National Research and Development Project of China funderid: 2020YFC0841100 – fundername: National Mega projects of China for Major Infectious Diseases funderid: 2017ZX10304402 – fundername: Fundamental Research Funds for CAMS of China funderid: 2020HY320001 – fundername: National Key Research and Development Project of China funderid: 2016YFD0500304 – fundername: the National Research and Development Project of China grantid: 2020YFC0841100 – fundername: Fundamental Research Funds for CAMS of China grantid: 2020HY320001 – fundername: National Key Research and Development Programme of China grantid: 2016YFD0500301; 2020YFC0840800; 2020YFC0840900 – fundername: National Key Research and Development Project of China grantid: 2016YFD0500304 – fundername: National Mega projects of China for Major Infectious Diseases grantid: 2017ZX10304402 – fundername: CAMS initiative for Innovative Medicine of China grantid: 2016‐I2M‐2‐006 |
| GroupedDBID | -SE -S~ 0R~ 1OC 24P 8FE 8FH AAHBH AAHHS AAXDM ACCFJ ACCMX ACXQS ADBBV ADKYN ADPDF ADZMN ADZOD AEEZP AEQDE AFKRA AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS AOIJS AVUZU BBNVY BCNDV BENPR BHPHI CAJEE CCPQU EBS EJD EMOBN GROUPED_DOAJ HCIFZ HYE IAO IHR INH ITC LK8 M7P OK1 OVD OVEED PIMPY PROAC Q-- RPM TCJ TEORI TGQ U1G U5O WFFXF WIN AAYXX CITATION PHGZM PHGZT NPM AAMMB ABUWG AEFGJ AGXDD AIDQK AIDYY AZQEC COVID DWQXO GNUQQ PKEHL PQEST PQGLB PQQKQ PQUKI PRINS 7X8 7S9 L.6 5PM PUEGO |
| ID | FETCH-LOGICAL-c6768-7507003a868fc46c0f9d5244fe64a85201d21ffb88eef09f75da9c72a48613e3 |
| IEDL.DBID | DOA |
| ISSN | 2576-2095 2096-5451 |
| IngestDate | Wed Aug 27 01:31:52 EDT 2025 Thu Aug 21 18:21:41 EDT 2025 Fri Jul 11 18:40:11 EDT 2025 Fri Jul 11 05:36:15 EDT 2025 Wed Aug 13 04:14:57 EDT 2025 Wed Feb 19 02:11:51 EST 2025 Tue Jul 01 03:28:29 EDT 2025 Thu Apr 24 22:54:59 EDT 2025 Wed Jan 22 17:20:38 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | pathogenicity rhesus macaque model pneumonia SARS‐CoV‐2 |
| Language | English |
| License | Attribution-NonCommercial 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c6768-7507003a868fc46c0f9d5244fe64a85201d21ffb88eef09f75da9c72a48613e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 National Team for COVID‐19 animal model development. Pin Yu, Feifei Qi, Yanfeng Xu, Fengdi Li, Peipei Liu, and Jiayi Liu contributed equally to this work. |
| ORCID | 0000-0002-6261-1232 |
| OpenAccessLink | https://doaj.org/article/18328c11bd3d403294a49448b4dcc5ea |
| PMID | 32318665 |
| PQID | 2391301677 |
| PQPubID | 4365297 |
| PageCount | 5 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_18328c11bd3d403294a49448b4dcc5ea pubmedcentral_primary_oai_pubmedcentral_nih_gov_7167234 proquest_miscellaneous_2718375679 proquest_miscellaneous_2393591967 proquest_journals_2391301677 pubmed_primary_32318665 crossref_primary_10_1002_ame2_12108 crossref_citationtrail_10_1002_ame2_12108 wiley_primary_10_1002_ame2_12108_AME212108 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | March 2020 |
| PublicationDateYYYYMMDD | 2020-03-01 |
| PublicationDate_xml | – month: 03 year: 2020 text: March 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Animal models and experimental medicine |
| PublicationTitleAlternate | Animal Model Exp Med |
| PublicationYear | 2020 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2005; 206 2020; 382 2020; 63 2020 2020; 395 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_4_1 e_1_2_7_3_1 Letko M (e_1_2_7_6_1) 2020 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 Bao L (e_1_2_7_12_1) 2020 Yang Y (e_1_2_7_5_1) 2020 e_1_2_7_2_1 |
| References_xml | – year: 2020 article-title: Early transmission dynamics in Wuhan, China, of novel coronavirus‐infected pneumonia publication-title: N Engl J Med – volume: 395 start-page: 565 issue: 10224 year: 2020 end-page: 574 article-title: Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding publication-title: Lancet – year: 2020 article-title: Functional assessment of cell entry and receptor usage for lineage B β‐coronaviruses, including 2019‐nCoV publication-title: bioRxiv – volume: 63 start-page: 457 issue: 3 year: 2020 end-page: 460 article-title: Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission publication-title: Science China. Life sciences – volume: 382 start-page: 727 issue: 8 year: 2020 end-page: 733 article-title: A novel coronavirus from patients with pneumonia in China, 2019 publication-title: N Engl J Med – volume: 206 start-page: 251 issue: 3 year: 2005 end-page: 259 article-title: An animal model of SARS produced by infection of with SARS coronavirus publication-title: J Pathol – year: 2020 article-title: Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China publication-title: medRxiv – volume: 395 start-page: 497 issue: 10223 year: 2020 end-page: 506 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet – year: 2020 article-title: The Pathogenicity of SARS‐CoV‐2 in hACE2 Transgenic Mice publication-title: bioRxiv – year: 2020 – ident: e_1_2_7_2_1 doi: 10.1056/NEJMoa2001017 – ident: e_1_2_7_3_1 doi: 10.1056/NEJMoa2001316 – ident: e_1_2_7_7_1 doi: 10.1016/S0140-6736(20)30251-8 – ident: e_1_2_7_9_1 doi: 10.1002/path.1769 – ident: e_1_2_7_10_1 – year: 2020 ident: e_1_2_7_12_1 article-title: The Pathogenicity of SARS‐CoV‐2 in hACE2 Transgenic Mice publication-title: bioRxiv – ident: e_1_2_7_4_1 – ident: e_1_2_7_11_1 doi: 10.1016/S0140-6736(20)30183-5 – year: 2020 ident: e_1_2_7_5_1 article-title: Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China publication-title: medRxiv – year: 2020 ident: e_1_2_7_6_1 article-title: Functional assessment of cell entry and receptor usage for lineage B β‐coronaviruses, including 2019‐nCoV publication-title: bioRxiv – ident: e_1_2_7_8_1 doi: 10.1007/s11427-020-1637-5 |
| SSID | ssj0002013406 ssib051367487 ssib039590021 ssib051604368 |
| Score | 2.5498838 |
| Snippet | Background
Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in... Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan,... BackgroundSince December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in... BACKGROUND: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2)... Abstract Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 93 |
| SubjectTerms | Alveoli Animal models animals Antigens Blood chest China Coronaviruses COVID-19 COVID-19 infection death Drug development Edema Epithelial cells epithelium Genomes histopathology Immune response inflammation Laboratory animals lungs Lymphocytes Macaca mulatta Macrophages medicine Monkeys & apes pathogenicity Pneumonia Public health Replication rhesus macaque model SARS‐CoV‐2 Septum Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus Severe acute respiratory syndrome coronavirus 2 Short Communication Short Communications therapeutics virus replication Viruses X-radiation |
| SummonAdditionalLinks | – databaseName: ProQuest Central Database Suite (ProQuest) dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5Be0FCFeWZUlAQXECKGjtObJ_Qtt2qILUgVFBvkZ8tUpu0m-6dn8Bv5JcwdrKhK6q9RfFYiceep-1vAN6hhTRMGJ1xIXUWShpnWpFwxt07lVNthQ0J_aPj6vA7-3xang4Jt244VrnQiVFR29aEHPkOLSSqW1Jx_vHqOgtVo8Lu6lBC4z6sowoWGHyt706Pv34bsyxo3go0WSMuKd1Rl44GSIVQT_KWJYqA_Xd5mf8flrztxEYrdPAINgb3MZ30870J91zzGB72ube0v1L0BMjkzP359TteU3E2nZ27bt6ll8oo_Ggaa990aevTvS8_Pu0jIZFP4eRgerJ3mA2lETJTYYCQoZ3nKI9KVMIbVpncS1uipfauYkqUOGxLifdaCOd8Lj0vrZKGU8VEFfKez2CtaRv3AtKCWgwkK-fyUmN3qrUmuZaUG-sJ9kzg_YJLtRlgw0P1iou6BzymdeBoHTmawNuR9qoHy7iTajcwe6QIANfxRTs7qwd5qYOmEYYQbQvL8oJKppjEUFIza0zpVALbi6mqB6nr6n9rJIE3YzPKS9gEUY1r55GmKCXqnVU0aLALXlZcJvC8n_3xbwt0iANGYAJ8aV0sDWe5pfl5HnG7MTTltGAJfIgraAWL6snRlManrdXjfAkPaEgAxENx27B2M5u7V-gl3ejXgyj8BSyoEMk priority: 102 providerName: ProQuest – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaq9sIFgXgFCgqCC0hR41dsS1y2LxWkAoeCeov8bCvRLNp07_wEfiO_hBknm3ZFVYlblIyVeOzxNzOxvyHkLSCkF9q7SmnjKixpXDlLcY97irZmLuiACf3jz83RN_HpVJ5ukA-rszADP8SUcEPLyOs1Grh1_c41aai9jAy5EfCk7xaerUXmfCa-ThkWgDYucnFNdKphOhg58ZOynevma4iUiftv8zb_3TR505nNaHT4gNwf3chyNoz7Q7IRu0eEzs7in1-_8_GUGMrFeeyXfXlpvYWXlLnmTV_OU7n35fvHfRCk5jE5OTw42TuqxpIIlW8gMKgA3xXYodWNTl40vk4mSEDoFBthtYQuB0ZTclrHmGqTlAzWeMWs0A3mO5-QzW7exWek5CxAANnEWEsHzZlzjtbOMOVDotCyIO9WWmn9SBeOVSt-tAPRMWtRg23WYEHeTLI_B5KMW6V2UbmTBBJb5xvzxVk72kmLK4z2lLrAg6g5M8IKAyGkE8F7GW1BtldD047W1reMG4Bi2ihVkNfTY7AT_PlhuzhfZhkuDaw3d8kAUHMlG2UK8nQY7elrOTjCyA1YELU2D9a6s_6kuzjPfN0QkirGRUHe5xlzh4ra2fEBy1fP_0f4BbnHMA2Qt8Ztk82rxTK-BF_pyr3KJvEXN8EMwg priority: 102 providerName: Wiley-Blackwell |
| Title | Age‐related rhesus macaque models of COVID‐19 |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fame2.12108 https://www.ncbi.nlm.nih.gov/pubmed/32318665 https://www.proquest.com/docview/2391301677 https://www.proquest.com/docview/2393591967 https://www.proquest.com/docview/2718375679 https://pubmed.ncbi.nlm.nih.gov/PMC7167234 https://doaj.org/article/18328c11bd3d403294a49448b4dcc5ea |
| Volume | 3 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BuXBBIF6BsgqCC0hR40f8OG7LVgVpS4UK6i3yk4JoFnW7V8RP4DfySxg7abQrqnLhEkXxWLFn7HwztvMNwEtESMeVs5VU2lYppXFlDUln3GMwNbVe-bSgPz8UBx_5u5PmZC3VVzoT1tMD94rbSUNOOUKsZ57XjGpuuMaYwnLvXBOya4SYtxZMfc3ba4QhVI18pHTHnAWaqBRSHsk1BMpE_Vd5l38fklx3XjP67N-FO4PbWE775t6DG6G7D2T6Ofz--Sv_jhJ8eX4alqtleWacwZeUOcfNslzEcu_9p7dvUJDoB3C8PzveO6iGFAiVExgIVIjnEuedUUJFx4Wro_YNInIMghvVYDc9JTFapUKItY6y8UY7SQ1XIq1vPoStbtGFx1Ay6jFgFCHUjcXq1FpLaqupdD4SrFnAq0uttG6gB09ZKr61PbExbZMG26zBAl6Mst97UowrpXaTckeJRGSdH6B528G87b_MW8D2pWnaYXYtW8o0Qi8RUhbwfCzGeZE2O0wXFqsswxqN35frZBCYmWyE1AU86q09tpah45u4AAuQG-NgozubJd2X08zPjSGopIwX8DqPmGtU1E7nM5rvnvwPZT2F2zQtB-QjctuwdXG-Cs_QZ7qwE7hJ-dEEbu3ODo8-TPJkwev8x-wP3uMWOQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtNAcFTSA0gI8cZQwAg4gGTVXq-93gNCaZsqoU1AKKDeVvtyW6l1StIIceMT-BF-ii9hdu2YRlS59WbZs7Z3dt47OwPwCjWkpoVWESu4ilxL40jJxOW4l1bGRJnCuID-cJT3v9APB9nBGvxenIVxaZULmegFtZloFyPfJClHcZvkjL0_-xa5rlFud3XRQqMmiz374zu6bLN3gx1c39eE7PbG2_2o6SoQ6Rxt6whVJENSlkVelJrmOi65yVDJlTansshQIRqSlKUqCmvLmJcsM5JrRiQtchcyxNdeg3WaoifTgfWt3ujT5zaog4NT1JBtGVSyKU8tcRUcXPvKC4rP9we4zKj9Pzfzos3sld7ubbjVWKthtyavO7Bmq7twsw71hfUJpnuQdA_tn5-__KkYa8LpkZ3NZ-Gp1BI_GvpWO7NwUobbH78OdhAw4fdhfBU4ewCdalLZRxCmxKDfmlsbZwqHE6VUEitOmDZlgiMDeLPAktBNlXLXLONE1PWViXAYFR6jAbxsYc_q2hyXQm05ZLcQrp62vzGZHoqGPYUTbIVOEmVSQ-OUcCopR89VUaN1ZmUAG4ulEg2Tz8Q_kgzgRfsY2dPtucjKTuYeJs04irlVMGgfpCzLGQ_gYb367d-maH-7koQBsCW6WJrO8pPq-MiXCUdPmJGUBvDWU9AKFInusEf81ePV83wO1_vj4b7YH4z2nsAN4mIPPh9vAzrn07l9igbauXrWsEUI4ooZ8S8TVUv4 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtNAcFRSCSEhxBtDASPgAJIVe_1Y7wGhtEnUUBoqVFBvq322ldq4JI0QNz6B3-F3-BJm145pRJVbb5Y9a3tn572zMwCvUEOqrFQyoiWTkWtpHEmRuBx3a0RMpC61C-jvjovtL9mHg_xgDX4vzsK4tMqFTPSCWlfKxci7JGUobpOC0q5t0iL2-sP3Z98i10HK7bQu2mnUJLJjfnxH9232btTHtX5NyHCwv7UdNR0GIlWgnR2huqRI1qIsSquyQsWW6RwVnjVFJsoclaMmibWyLI2xMbM014IpSkRWFi58iK-9BusUnaK4A-ubg_He5zbAg4NT1JZtSVTSFaeGuGoOrpXlBSXoewVcZuD-n6d50X72CnB4G241lmvYq0ntDqyZyV24WYf9wvo00z1Ieofmz89f_oSM0eH0yMzms_BUKIEfDX3bnVlY2XDr09dRHwETdh_2rwJnD6AzqSbmEYQp0ejDFsbEucThREqZxJIRqrRNcGQAbxZY4qqpWO4aZ5zwutYy4Q6j3GM0gJct7Fldp-NSqE2H7BbC1db2N6rpIW9YlTshV6okkTrVWZwSlomMoRcrM61UbkQAG4ul4g3Dz_g_8gzgRfsYWdXtv4iJqeYeJs0ZirxVMGgrpDQvKAvgYb367d-maIu78oQB0CW6WJrO8pPJ8ZEvGY5eMSVpFsBbT0ErUMR7uwPirx6vnudzuI4MyD-OxjtP4AZxYQifmrcBnfPp3DxFW-1cPmu4IgR-xXz4F5ZJUC0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Age%E2%80%90related+rhesus+macaque+models+of+COVID%E2%80%9019&rft.jtitle=Animal+models+and+experimental+medicine&rft.au=Pin+Yu&rft.au=Feifei+Qi&rft.au=Yanfeng+Xu&rft.au=Fengdi+Li&rft.date=2020-03-01&rft.pub=Wiley&rft.eissn=2576-2095&rft.volume=3&rft.issue=1&rft.spage=93&rft.epage=97&rft_id=info:doi/10.1002%2Fame2.12108&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_18328c11bd3d403294a49448b4dcc5ea |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2576-2095&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2576-2095&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2576-2095&client=summon |