Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

• Published in: Aging cell Vol. 13; no. 4; pp. 690 - 698
• Main Authors: Hazeldine, Jon, Harris, Phillipa, Chapple, Iain L., Grant, Melissa, Greenwood, Hannah, Livesey, Amy, Sapey, Elizabeth, Lord, Janet M.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2014; BlackWell Publishing Ltd
• Subjects: Acetic acid; Adult; Age; Aged; Aging; Aging - immunology; Aging - pathology; Analysis; Bacteria; Case-Control Studies; Chronic Disease; CXCR2 protein; Defects; Disease susceptibility; Enzyme Activation - drug effects; Enzymes; Extracellular Traps - drug effects; Extracellular Traps - immunology; Female; Gum disease; Health aspects; Humans; Hypochlorous acid; Immune response; Immune system; Immunity, Innate - drug effects; Immunity, Innate - immunology; Infection; Infections; Innate immunity; Interleukin-8 - metabolism; Kinases; Leukocytes (neutrophilic); Lipopolysaccharides; Lipopolysaccharides - pharmacology; Male; MAP kinase; Medical research; Medicine, Experimental; Microscopy; Middle Aged; neutrophil; neutrophil extracellular traps; Neutrophils; Neutrophils - drug effects; Neutrophils - immunology; Older people; Original; p38 Mitogen-Activated Protein Kinases - metabolism; Pathogens; Periodontitis; Periodontitis - immunology; Periodontitis - pathology; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Cell Surface - metabolism; Risk factors; TLR4 protein; Toll-like receptors; Tumor necrosis factor; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-TNF; neutrophil extracellular traps; aging; neutrophil; periodontitis

Summary Neutrophil extracellular traps (NETs) are a recently discovered addition to the defensive armamentarium of neutrophils, assisting in the immune response against rapidly dividing bacteria. Although older adults are more susceptible to such infections, no study has examined whether aging in hu...