Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals - Hazeldine, Jon; Harris, Phillipa; Chapple, Iain L.; Grant, Melissa; Greenwood, Hannah; Livesey, Amy; Sapey, Elizabeth; Lord, Janet M. (Aging cell, 2014)
Keywords: Acetic acid; Adult; Age; Aged; Aging; Aging - immunology; Aging - pathology; Analysis; Bacteria; Case-Control Studies; Chronic Disease; CXCR2 protein; Defects; Disease susceptibility; Enzyme Activation - drug effects; Enzymes; Extracellular Traps - drug effects; Extracellular Traps - immunology; Female; Gum disease; Health aspects; Humans; Hypochlorous acid; Immune response; Immune system; Immunity, Innate - drug effects; Immunity, Innate - immunology; Infection; Infections; Innate immunity; Interleukin-8 - metabolism; Kinases; Leukocytes (neutrophilic); Lipopolysaccharides; Lipopolysaccharides - pharmacology; Male; MAP kinase; Medical research; Medicine, Experimental; Microscopy; Middle Aged; neutrophil; neutrophil extracellular traps; Neutrophils; Neutrophils - drug effects; Neutrophils - immunology; Older people; Original; p38 Mitogen-Activated Protein Kinases - metabolism; Pathogens; Periodontitis; Periodontitis - immunology; Periodontitis - pathology; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Cell Surface - metabolism; Risk factors; TLR4 protein; Toll-like receptors; Tumor necrosis factor; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-TNF; neutrophil extracellular traps; aging; neutrophil; periodontitis