Longitudinal decline in peak V̇o 2 with aging in a healthy population is associated with a reduction in peripheral oxygen utilization but not in cardiac output

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 327; no. 2; pp. H509 - H517
• Main Authors: AlGhatrif, Majd, Morrell, Christopher H, Fleg, Jerome L, Chantler, Paul D, Najjar, Samer S, Becker, Lewis C, Ferrucci, Luigi, Gerstenblith, Gary, Lakatta, Edward G
• Format: Journal Article
• Language: English
• Published: United States 01.08.2024
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Aging - metabolism; Aging - physiology; Baltimore; Cardiac Output; Exercise Test; Exercise Tolerance; Female; Humans; Longitudinal Studies; Male; Middle Aged; Oxygen Consumption - physiology; Young Adult; Baltimore; cardiac output; arteriovenous oxygen difference; aging; peak oxygen consumption; aerobic capacity

Aging is associated with a significant decline in aerobic capacity assessed by maximal exercise oxygen consumption (V̇o ). The relative contributions of the specific V̇o components driving this decline, namely cardiac output (CO) and arteriovenous oxygen difference (A - V)O , remain unclear. We exam...