Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice

Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic a...

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Published inPLoS neglected tropical diseases Vol. 15; no. 12; p. e0010050
Main Authors Wu, Yifan, Li, Evan, Knight, Morgan, Adeniyi-Ipadeola, Grace, Song, Li-Zhen, Burns, Alan R, Gazzinelli-Guimaraes, Ana Clara, Fujiwara, Ricardo, Bottazzi, Maria Elena, Weatherhead, Jill E
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.12.2021
Public Library of Science (PLoS)
Subjects
Allergic diseases
Anaemia
Anemia
Anemia - genetics
Anemia - immunology
Anemia - parasitology
Anemia - pathology
Animals
Ascariasis
Ascariasis - genetics
Ascariasis - immunology
Ascariasis - parasitology
Ascariasis - pathology
Ascaris
Ascaris suum - genetics
Ascaris suum - physiology
Asthma
Biology and Life Sciences
Chemokines
Chronic Disease
Chronic obstructive pulmonary disease
Complications and side effects
Cytokines
Cytokines - genetics
Cytokines - immunology
Defence mechanisms
Development and progression
Developmental stages
Diseases
Emphysema
Female
Haemorrhage
Health aspects
Hemorrhage
Humans
Immune response
Immunity
Infections
Inflammation
Larva - genetics
Larva - physiology
Larvae
Larval development
Larval stage
Lavage
Ligands
Lung - immunology
Lung - parasitology
Lung - pathology
Lung diseases
Lung Diseases - genetics
Lung Diseases - immunology
Lung Diseases - parasitology
Lung Diseases - pathology
Lungs
Medicine and Health Sciences
Mice
Mice, Inbred BALB C
Morbidity
Obstructive lung disease
Parasites
Pathology
Research and Analysis Methods
Respiratory system
Respiratory tract diseases
Risk factors
Tropical diseases
United States
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Abstract Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions.
AbstractList Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host’s lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions.
Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host’s lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions.
Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host’s lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions. Ascariasis is the most common helminth infection and leads to significant global morbidity. Transient Ascaris larval migration through the host’s lungs is essential for larval development but leads to an exaggerated type-2 host immune response. Our work demonstrates that transient Ascaris spp. larval migration through the lungs has significant long-term consequences including changes in lung structure and function as well as vascular damage causing chronic lung disease and anemia. We propose that Ascaris spp. larval migration through the host lungs is a risk factor for the development of chronic lung disease and anemia in parasite-endemic regions globally.
Audience Academic
Author Burns, Alan R
Gazzinelli-Guimaraes, Ana Clara
Knight, Morgan
Adeniyi-Ipadeola, Grace
Weatherhead, Jill E
Song, Li-Zhen
Fujiwara, Ricardo
Bottazzi, Maria Elena
Wu, Yifan
Li, Evan
AuthorAffiliation 3 College of Optometry, University of Houston, Houston, Texas, United States of America
5 National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America
University of Utah, UNITED STATES
6 Texas Children’s Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, Texas, United States of America
7 Department of Medicine, Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America
1 Department of Pediatrics, Pediatric Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America
4 Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
2 Department of Medicine, Pathology and Immunology, and the Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas, United States of America
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SSID ssj0059581
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Snippet Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's...
Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host’s...
Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host’s...
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doaj
pubmedcentral
proquest
gale
crossref
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Open Access Repository
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Index Database
StartPage e0010050
SubjectTerms Allergic diseases
Anaemia
Anemia
Anemia - genetics
Anemia - immunology
Anemia - parasitology
Anemia - pathology
Animals
Ascariasis
Ascariasis - genetics
Ascariasis - immunology
Ascariasis - parasitology
Ascariasis - pathology
Ascaris
Ascaris suum - genetics
Ascaris suum - physiology
Asthma
Biology and Life Sciences
Chemokines
Chronic Disease
Chronic obstructive pulmonary disease
Complications and side effects
Cytokines
Cytokines - genetics
Cytokines - immunology
Defence mechanisms
Development and progression
Developmental stages
Diseases
Emphysema
Female
Haemorrhage
Health aspects
Hemorrhage
Humans
Immune response
Immunity
Infections
Inflammation
Larva - genetics
Larva - physiology
Larvae
Larval development
Larval stage
Lavage
Ligands
Lung - immunology
Lung - parasitology
Lung - pathology
Lung diseases
Lung Diseases - genetics
Lung Diseases - immunology
Lung Diseases - parasitology
Lung Diseases - pathology
Lungs
Medicine and Health Sciences
Mice
Mice, Inbred BALB C
Morbidity
Obstructive lung disease
Parasites
Pathology
Research and Analysis Methods
Respiratory system
Respiratory tract diseases
Risk factors
Tropical diseases
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Title Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice
URI https://www.ncbi.nlm.nih.gov/pubmed/34914687
https://www.proquest.com/docview/2620112742
https://search.proquest.com/docview/2611652795
https://pubmed.ncbi.nlm.nih.gov/PMC8717995
https://doaj.org/article/9aacc5138edf459eba62a113517836c7
http://dx.doi.org/10.1371/journal.pntd.0010050
Volume 15
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