Reduction in Plasmodium falciparum Pfk13 and pfg377 allele diversity through time in southern Vietnam

• Published in: Tropical medicine and health Vol. 50; no. 1; p. 19
• Main Authors: Thieu, Nguyen Quang, Chinh, Vu Duc, Van Hanh, Truong, Van Dung, Nguyen, Takagi, Hidekazu, Annoura, Takeshi, Kawai, Satoru, Masuda, Gaku, Van Tuan, Nguyen, Hung, Vu Viet, Nakazawa, Shusuke, Culleton, Richard, Binh, Nguyen Thi Huong, Maeno, Yoshimasa
• Format: Journal Article
• Language: English
• Published: Japan BioMed Central 01.03.2022; BMC
• Subjects: Artemisinin resistance; Gametocyte; K13-propeller gene; pfg377 gene; Plasmodium falciparum; Short Report; Vietnam; Artemisinin resistance; Plasmodium falciparum; pfg377 gene; Vietnam; Gametocyte; K13-propeller gene

Plasmodium falciparum has acquired resistance to artemisinin in Southeast Asia, with mutations in the P. falciparum Kelch-13 (Pfk13) gene associated with the resistance phenotype. The widespread use of Artemisinin-based combination therapy (ACT)s in Southeast Asia has led to the selection and spread...