Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles

• Published in: Journal of allergy and clinical immunology Vol. 136; no. 3; pp. 638 - 648
• Main Authors: Persson, Helena, Kwon, Andrew T., Ramilowski, Jordan A., Silberberg, Gilad, Söderhäll, Cilla, Orsmark-Pietras, Christina, Nordlund, Björn, Konradsen, Jon R., de Hoon, Michiel J.L., Melén, Erik, Hayashizaki, Yoshihide, Hedlin, Gunilla, Kere, Juha, Daub, Carsten O.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015; Elsevier Limited
• Subjects: Adolescent; Allergy and Immunology; Asthma; Asthma - drug therapy; Asthma - genetics; Asthma - pathology; Case-Control Studies; Child; Child, Preschool; childhood asthma; Drug Resistance - genetics; Female; Gene expression; Gene Expression Profiling; Genome-Wide Association Study; Glucocorticoids - therapeutic use; Humans; JNK Mitogen-Activated Protein Kinases - genetics; long noncoding RNA; Male; Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics; peripheral blood leukocytes; Receptors, Glucocorticoid - genetics; RNA polymerase; RNA, Messenger - genetics; Severity of Illness Index; Therapy-resistant asthma; Transcriptome; MARA; peripheral blood leukocytes; CAGE; Therapy-resistant asthma; transcriptome; GO; GLM; RORA; childhood asthma; MAPK; SA; TC; TF; CTRL; SNP; TSS; long noncoding RNA; LD; KEGG; lincRNA; NK; CA; Generalized linear model; Linkage disequilibrium; Long intergenic noncoding RNA; Tag cluster; Cap Analysis of Gene Expression; Transcription start site; Healthy control subject; Transcription factor; Gene Ontology; Motif Activity Response Analysis; Kyoto Encyclopedia of Genes and Genomes; Mitogen-activated protein kinase; RAR-related orphan receptor A; Natural killer; Controlled persistent asthma; Single nucleotide polymorphism

Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoki...