Microbial Chassis Development for Natural Product Biosynthesis

• Published in: Trends in biotechnology (Regular ed.) Vol. 38; no. 7; pp. 779 - 796
• Main Authors: Xu, Xianhao, Liu, Yanfeng, Du, Guocheng, Ledesma-Amaro, Rodrigo, Liu, Long
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2020; Elsevier Limited; Elsevier
• Subjects: Antibiotics; Artificial intelligence; Big Data; Binding sites; biochemical pathways; Biosynthesis; Carbon; Chassis; chassis cells; Construction; E coli; Enzymes; Flavonoids; Functional foods & nutraceuticals; Gene expression; Genetic engineering; genome mining; Genomes; Identification; Internal Medicine; Metabolic engineering; Metabolism; Metabolites; Microorganisms; Natural products; Proteins; Synthetic biology; systems metabolic engineering; chassis cells; natural products; synthetic biology; systems metabolic engineering

Engineering microbial cells to efficiently synthesize high-value-added natural products has received increasing attention in recent years. In this review, we describe the pipeline to build chassis cells for natural product production. First, we discuss recently developed genome mining strategies for...