C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis: a novel link between complement and epithelial cell survival

• Published in: PloS one Vol. 2; no. 1; p. e159
• Main Authors: Williams, Kevin T, Young, Steven P, Negus, Alison, Young, Lawrence S, Adams, David H, Afford, Simon C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.01.2007; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Apoptosis; Apoptosis - immunology; B cells; Bile; Biochemistry; Biomedical research; C4b-binding protein; CD40 antigen; CD40 Antigens - immunology; CD40 Ligand - immunology; CD40L protein; Cell activation; Cell Biology; Cell Biology/Cell Growth and Division; Cell Biology/Cell Signaling; Cell Biology/Cellular Death and Stress Responses; Cell growth; Cell Proliferation; Cell surface; Cell survival; Cell Survival - immunology; Cells, Cultured; Complement; Complement activation; Complement C4b-Binding Protein - immunology; Complement System Proteins - immunology; Coordination compounds; Cytokines; Epithelial cells; Epithelial Cells - immunology; Gastroenterology and Hepatology; Gastroenterology and Hepatology/Biliary Tract; Gastroenterology and Hepatology/Gastrointestinal Cancers; Gel filtration; Gene expression; Hepatocytes; Humans; Immune system; Immunohistochemistry; Intracellular signalling; JNK Mitogen-Activated Protein Kinases - immunology; Ligands; Liver; Liver - cytology; Liver - immunology; Liver cancer; Liver diseases; Localization; Medical research; Molecular weight; NF-kappa B - immunology; NF-κB protein; Prevention; Protein binding; Protein synthesis; Proteins; Proto-Oncogene Proteins c-fos - immunology; Receptors; Rodents; Signal transduction; STAT3 Transcription Factor - immunology; Surface Plasmon Resonance; Survival; TNF inhibitors; Transcription factors; Tumor necrosis factor; Tumor necrosis factor-TNF

Activation of CD40 on hepatocytes and cholangiocytes is critical for amplifying Fas-mediated apoptosis in the human liver. C4b-Binding Protein (C4BP) has been reported to act as a potential surrogate ligand for CD40, suggesting that it could be involved in modulating liver epithelial cell survival....