Low-dose erythromycin in pediatrics: Formulation and stability of 20 mg hard gelatin capsules

• Published in: PloS one Vol. 18; no. 2; p. e0282164
• Main Authors: Thevin, Patrick, Curti, Christophe, Benech, Alexandre, Jean, Christophe, Lamy, Edouard, Castera Ducros, Caroline, Primas, Nicolas, Bertault-Peres, Pierre, Vanelle, Patrice
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.02.2023; Public Library of Science (PLoS)
• Subjects: Ambient temperature; Anti-Bacterial Agents; Antibiotics; Biology and Life Sciences; Capsules - chemistry; Cellulose; Child; Chromatography; Complications and side effects; Conformity; Crystalline cellulose; Cytokines; Erythromycin; Gelatin; Health aspects; Human health and pathology; Humans; Hépatology and Gastroenterology; Infant, Newborn; Infants (Premature); Life Sciences; Medicine and Health Sciences; Neonates; Newborn babies; Nutrition; Parenteral nutrition; Patient outcomes; Pediatrics; People and Places; Pharmaceutical sciences; Pharmacology; Physical Sciences; Research and Analysis Methods; Risk groups; Room temperature; Stability; France; United States > US

Erythromycin is a macrolide antibiotic that is also prescribed off-label in premature neonates as a prokinetic agent. There is no oral formulation with dosage and/or excipients adapted for these high-risk patients. Clinical studies of erythromycin as a prokinetic agent were reviewed. Capsules of 20...