Enhanced Immunomodulatory Activity and Stability in Simulated Digestive Juices of Lactobacillus plantarum L-137 by Heat Treatment
This study reports the effect of heat treating Lactobacillus plantarum L-137 on its in vitro cytokine-inducing activity, on the stability of this activity in simulated digestive juices, and on its in vivo immunomodulatory properties. L-137 cells were harvested at the stationary phase with or without...
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Published in | Bioscience, biotechnology, and biochemistry Vol. 76; no. 5; pp. 918 - 922 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
Japan Society for Bioscience, Biotechnology, and Agrochemistry
2012
Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press |
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Abstract | This study reports the effect of heat treating Lactobacillus plantarum L-137 on its in vitro cytokine-inducing activity, on the stability of this activity in simulated digestive juices, and on its in vivo immunomodulatory properties. L-137 cells were harvested at the stationary phase with or without the subsequent heat treatment and then lyophilized. Heat-killed L-137 cells stimulated mouse spleen cells to produce more interleukin-12p40 than unheated L-137. The interleukin-12p40-inducing activity of unheated L-137 was significantly lower when incubated with simulated intestinal juice, but the activity of heat-killed L-137 cells was maintained. Furthermore, heat-killed L-137 was more protective than unheated L-137 in a mouse model of dextran sulfate sodium-induced colitis. A heat treatment may therefore be effective for enhancing the immunomodulatory activity of L-137 cells. |
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AbstractList | This study reports the effect of heat treating Lactobacillus plantarum L-137 on its in vitro cytokine-inducing activity, on the stability of this activity in simulated digestive juices, and on its in vivo immunomodulatory properties. L-137 cells were harvested at the stationary phase with or without the subsequent heat treatment and then lyophilized. Heat-killed L-137 cells stimulated mouse spleen cells to produce more interleukin-12p40 than unheated L-137. The interleukin-12p40-inducing activity of unheated L-137 was significantly lower when incubated with simulated intestinal juice, but the activity of heat-killed L-137 cells was maintained. Furthermore, heat-killed L-137 was more protective than unheated L-137 in a mouse model of dextran sulfate sodium-induced colitis. A heat treatment may therefore be effective for enhancing the immunomodulatory activity of L-137 cells. |
Author | YAMAMOTO, Yoshihiro FUJIKI, Takashi MUROSAKI, Shinji HIROSE, Yoshitaka |
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Keywords | Lactic acid bacteria Heat treatment Lactobacillus plantarum Stability Immunomodulation Cytokine dextran sulfate sodium (DSS)-induced colitis Interleukin 12 simulated digestive juice Sulfates interleukin (IL)-12 Dextran Sodium Bacteria Lactobacillaceae Colitis |
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SubjectTerms | Animals Biological and medical sciences Biomimetic Materials - chemistry Biomimetic Materials - pharmacology Cells, Cultured Colitis - chemically induced Colitis - immunology Colitis - prevention & control Computer simulation Dextran Sulfate - administration & dosage dextran sulfate sodium (DSS)-induced colitis Female Freeze Drying Fundamental and applied biological sciences. Psychology Gastric Juice - chemistry Heat treatment Hot Temperature Immunologic Factors - pharmacology interleukin (IL)-12 Interleukin-12 Subunit p40 - biosynthesis Interleukin-12 Subunit p40 - immunology Intestinal Secretions - chemistry Juices Lactobacillus plantarum Lactobacillus plantarum - chemistry Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Probiotics - pharmacology simulated digestive juice Simulation Spleen Spleen - cytology Spleen - drug effects Spleen - immunology Stability Sulfates |
Title | Enhanced Immunomodulatory Activity and Stability in Simulated Digestive Juices of Lactobacillus plantarum L-137 by Heat Treatment |
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