Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition - Inoue, Daichi; Polaski, Jacob T.; Taylor, Justin; Castel, Pau; Chen, Sisi; Kobayashi, Susumu; Hogg, Simon J.; Hayashi, Yasutaka; Pineda, Jose Mario Bello; El Marabti, Ettaib; Erickson, Caroline; Knorr, Katherine; et al. (Nature genetics, 2021)
Keywords: 38/91; 45/70; 45/91; 631/337/2019; 64; 64/60; 692/699/67/1990; 692/699/67/1990/1673; 692/699/67/1990/283; 692/699/67/71; 96/100; 96/31; Agriculture; Animal Genetics and Genomics; Animals; Base Sequence; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cell cycle; Cell Self Renewal; Cell Transformation, Neoplastic - pathology; Clone Cells; CRISPR; CRISPR-Cas Systems - genetics; Development and progression; Eukaryotes; Female; Females; Gene Function; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetic susceptibility; Genome, Human; Health aspects; Hematologic Diseases - genetics; Hematologic Diseases - pathology; Hematopoiesis; Hematopoietic stem cells; Hematopoietic Stem Cells - metabolism; Human Genetics; Humans; Introns; Introns - genetics; Leukemia; Male; Mice; Mice, Knockout; Mimicry; mRNA; mRNA turnover; Mutation; Myelodysplastic syndromes; Neoplasms - genetics; Noonan Syndrome - genetics; Noonan's syndrome; Oncology, Experimental; Pedigree; Proteins; Retention; Ribonucleoproteins - genetics; Ribonucleoproteins - metabolism; RNA - metabolism; RNA splicing; RNA Splicing - genetics; Solid tumors; Spleen - pathology; Splicing; Stem cells; Transcription Factors - genetics; Tumors; X chromosomes; Japan