Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk - Chiou, Joshua; Zeng, Chun; Cheng, Zhang; Han, Jee Yun; Schlichting, Michael; Miller, Michael; Mendez, Robert; Huang, Serina; Wang, Jinzhao; Sui, Yinghui; Deogaygay, Allison; Okino, Mei-Lin; et al. (Nature genetics, 2021)
Keywords: 45/23; 631/114/1314; 631/208/177; 692/699/2743/137/773; Accessibility; Agriculture; Animal Genetics and Genomics; Beta cells; Biomedical and Life Sciences; Biomedicine; Blood Glucose - metabolism; Cancer Research; Cell Differentiation; Chromatin; Chromatin - chemistry; Chromatin - metabolism; Combinatorial analysis; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Disease; Epigenomics; Fasting; Gene expression; Gene Expression Profiling; Gene Function; Genetic aspects; Genetic regulation; Genetic research; Genetics; Genome editing; Genome-wide association studies; Genome-Wide Association Study; Genomes; Glucagon-Secreting Cells - metabolism; Glucagon-Secreting Cells - pathology; Health risk assessment; Health risks; High-Throughput Nucleotide Sequencing; Human Embryonic Stem Cells - cytology; Human Genetics; Humans; Identification and classification; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Islet cells; KCNQ1 Potassium Channel - genetics; KCNQ1 Potassium Channel - metabolism; KCNQ1 protein; Multigene Family; Pancreas; Pancreatic beta cells; Pancreatic Polypeptide-Secreting Cells - metabolism; Pancreatic Polypeptide-Secreting Cells - pathology; Polymorphism, Genetic; Potassium channels (voltage-gated); Risk factors; Single-Cell Analysis; Somatostatin-Secreting Cells - metabolism; Somatostatin-Secreting Cells - pathology; Structure; Transcription factors; Transcription Factors - classification; Transcription Factors - genetics; Transcription Factors - metabolism; Transposase; Type 2 diabetes; United States