A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation

• Published in: PLoS genetics Vol. 13; no. 11; p. e1007072
• Main Authors: Oakes, Samantha R, Gallego-Ortega, David, Stanford, Prudence M, Junankar, Simon, Au, Wendy Wing Yee, Kikhtyak, Zoya, von Korff, Anita, Sergio, Claudio M, Law, Andrew M K, Castillo, Lesley E, Allerdice, Stephanie L, Young, Adelaide I J, Piggin, Catherine, Whittle, Belinda, Bertram, Edward, Naylor, Matthew J, Roden, Daniel L, Donovan, Jesse, Korennykh, Alexei, Goodnow, Christopher C, O'Bryan, Moira K, Ormandy, Christopher J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.11.2017; Public Library of Science (PLoS)
• Subjects: 2',5'-Oligoadenylate Synthetase - genetics; 2',5'-Oligoadenylate Synthetase - metabolism; Adenine Nucleotides - metabolism; Animals; Biology and life sciences; Cell Culture Techniques; Endoribonucleases - metabolism; Female; Genetic aspects; Humans; Lactation; Lactation - genetics; Mammary glands; Mammary Glands, Animal - metabolism; Medicine and Health Sciences; Mice; Milk; Mutation - genetics; Oligoribonucleotides - metabolism; Physiological aspects; RNA; RNA, Double-Stranded - metabolism; Signal Transduction - genetics

We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammar...