Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome - Jewell, Brittany E.; Xu, An; Zhu, Dandan; Huang, Mo-Fan; Lu, Linchao; Liu, Mo; Underwood, Erica L.; Park, Jun Hyoung; Fan, Huihui; Gingold, Julian A.; Zhou, Ruoji; Tu, Jian; et al. (PLoS genetics, 2021)
Keywords: Adenosine Triphosphate - biosynthesis; Analysis; Biology and Life Sciences; Care and treatment; Cell Proliferation - drug effects; Cell Respiration - drug effects; Cellular Senescence - genetics; Electron Transport Complex I - antagonists & inhibitors; Electron Transport Complex I - genetics; Gene expression; Gene Expression Regulation, Developmental - genetics; Genetic aspects; Humans; Induced Pluripotent Stem Cells - drug effects; Induced Pluripotent Stem Cells - metabolism; Medicine and Health Sciences; Mitogen-Activated Protein Kinase Kinases - genetics; Mutation - genetics; Osteoblasts - drug effects; Osteogenesis - genetics; Osteosarcoma; Osteosarcoma - complications; Osteosarcoma - genetics; Osteosarcoma - pathology; Oxadiazoles - pharmacology; Oxidative Phosphorylation - drug effects; Piperidines - pharmacology; RecQ Helicases - genetics; RNA, Long Noncoding - genetics; Rothmund-Thomson syndrome; Rothmund-Thomson Syndrome - complications; Rothmund-Thomson Syndrome - genetics; Rothmund-Thomson Syndrome - pathology; Stem cells; United States