Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii

• Published in: PLoS genetics Vol. 17; no. 12; p. e1009970
• Main Authors: Ingham, Victoria A., Tennessen, Jacob A., Lucas, Eric R., Elg, Sara, Yates, Henrietta Carrington, Carson, Jessica, Guelbeogo, Wamdaogo Moussa, Sagnon, N’Fale, Hughes, Grant L., Heinz, Eva, Neafsey, Daniel E., Ranson, Hilary
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.12.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Anopheles - genetics; Anopheles - pathogenicity; Biology and Life Sciences; DNA sequencing; Genetic aspects; Genomes; Genomics; Identification and classification; Insecticide Resistance - genetics; Insecticides - pharmacology; Malaria; Malaria - genetics; Malaria - transmission; Medicine and Health Sciences; Mosquito Control; Mosquito Vectors - genetics; Mosquito Vectors - pathogenicity; Nucleotide sequencing; Pesticide resistance; Pyrethrins - pharmacology; Research and Analysis Methods; RNA sequencing; RNA-Seq; Transcriptome - genetics; Whole Genome Sequencing - methods; United States; United Kingdom

Insecticide resistance is a major threat to gains in malaria control, which have been stalling and potentially reversing since 2015. Studies into the causal mechanisms of insecticide resistance are painting an increasingly complicated picture, underlining the need to design and implement targeted st...