Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

• Published in: Nature (London) Vol. 595; no. 7868; pp. 578 - 584
• Main Authors: Casanova-Acebes, María, Dalla, Erica, Leader, Andrew M., LeBerichel, Jessica, Nikolic, Jovan, Morales, Blanca M., Brown, Markus, Chang, Christie, Troncoso, Leanna, Chen, Steven T., Sastre-Perona, Ana, Park, Matthew D., Tabachnikova, Alexandra, Dhainaut, Maxime, Hamon, Pauline, Maier, Barbara, Sawai, Catherine M., Agulló-Pascual, Esperanza, Schober, Markus, Brown, Brian D., Reizis, Boris, Marron, Thomas, Kenigsberg, Ephraim, Moussion, Christine, Benaroch, Philippe, Aguirre-Ghiso, Julio A., Merad, Miriam
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.07.2021; Nature Publishing Group
• Subjects: 13; 14; 14/1; 14/28; 42; 42/41; 45; 45/91; 631/250/2504/342; 631/67/327; 64; 64/60; 692/308; 692/420; Adaptive immunity; Animals; Bioaccumulation; Bone marrow; Cancer cells; Carcinogenesis; Carcinoma, Non-Small-Cell Lung - pathology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Depletion; Development and progression; Epithelial-Mesenchymal Transition; Female; Gene sequencing; Health aspects; Hematopoietic stem cells; Humanities and Social Sciences; Humans; Immunity; Immunoregulation; Immunotherapy; Inflammation; Invasiveness; Lesions; Leukocytes; Life Sciences; Lung cancer; Lung cancer, Non-small cell; Lung carcinoma; Lung diseases; Lung Neoplasms - pathology; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - immunology; Male; Mesenchyme; Mice; Mice, Inbred C57BL; Microenvironments; Monocytes; multidisciplinary; Neoplasm Invasiveness; Non-small cell lung carcinoma; Phenotypes; Populations; Science; Science (multidisciplinary); Small cell lung carcinoma; Spatial distribution; Stem cell transplantation; Stem cells; T-Lymphocytes, Regulatory - immunology; Transcription factors; Transgenic animals; Tumor Microenvironment; Tumors; United States

Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and response to immunotherapy, which makes them an important target for cancer treatment 1 , 2 . However, modulating macrophages has proved extremely difficult, as we still lack a complete understanding of the...