Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis

• Published in: Intensive care medicine Vol. 39; no. 4; pp. 644 - 652
• Main Authors: Yamakawa, Kazuma, Ogura, Hiroshi, Fujimi, Satoshi, Morikawa, Miki, Ogawa, Yoshihito, Mohri, Tomoyoshi, Nakamori, Yasushi, Inoue, Yoshiaki, Kuwagata, Yasuyuki, Tanaka, Hiroshi, Hamasaki, Toshimitsu, Shimazu, Takeshi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.04.2013; Springer; Springer Nature B.V
• Subjects: Acuity; Aged; Anesthesiology; Anticoagulants; APACHE; Care and treatment; Cohort analysis; Comparative analysis; Critical care; Critical Care Medicine; Disseminated intravascular coagulation; Disseminated Intravascular Coagulation - drug therapy; Disseminated Intravascular Coagulation - etiology; Disseminated Intravascular Coagulation - mortality; Emergency Medicine; Female; Health aspects; Hospital Mortality; Hospitals; Humans; Infection; Intensive; Intensive care; Intensive Care Units; Japan; Male; Medical referrals; Medicine; Medicine & Public Health; Middle Aged; Mortality; Multicenter Studies as Topic; Original; Pain Medicine; Pediatrics; Pneumology/Respiratory System; Propensity Score; Regression Analysis; Respiration, Artificial - statistics & numerical data; Retrospective Studies; Sepsis; Sepsis - complications; Sepsis - drug therapy; Sepsis - mortality; Tertiary Care Centers; Thrombomodulin - administration & dosage; Thrombomodulin - therapeutic use; Treatment Outcome; Ventilators; Japan; Sepsis; Retrospective studies; Thrombomodulin; Outcome assessment; Anticoagulant therapy; DIC

Purpose Evidence of efficacy and safety of, and especially mortality related to, recombinant human thrombomodulin (rhTM) treatment for sepsis-induced disseminated intravascular coagulation (DIC) is limited. We hypothesized that patients with sepsis-induced DIC receiving treatment with rhTM would hav...